摘要
目的:观察醋酸氯已定口腔消毒液的消毒效果和毒理学安全性。方法:采用定量杀菌试验和动物试验进行研究。结果:该口腔消毒液对大肠杆菌和金葡球菌作用0.5 min杀灭对数值均>5.00;对白色念珠菌作用0.5 min杀灭对数值均>4.00;对皮肤表面自然菌作用1 min,平均杀灭对数值为>2.59,各次试验的杀灭对数值均>1.00。NIH小鼠,SD大鼠急性经口毒性试验结果为LD50均>5000 mg/kg;急性眼刺激试验属无刺激性500 mg/kg～5000 mg/kg剂量的小鼠微核试验未发现该受试样品对体细胞有诱变作用;该消毒液的最大未观察到有害作用剂量大于1000 mg/kg,未发现口腔消毒液对大鼠亚急性经口毒性的主要靶器官。结论:该消毒液杀菌效果好,对黏膜刺激性小,毒性低。
Objective ：To observe the disinfection effect and toxicity safety of oral chlorhexidine acetate disinfect solution. Methods： The study was carried out with quantitative bactericidal tests and animal tests. Results： The re- suits showed that the killing log values of Escherichia coli, Staphylococcus exposed to the disinfection solution for 0.5 min were all 〉 5.00, and that of Candida albicans exposed to the disinfection solution for 0.5 min was 〉 4.00 ; the mean kill logrithm of skin natural bacteria with 1 min was 〉 2.59, the mean kill logrithm of all tests was 〉 1.00. The acute oral toxicity test in NIH little rats and SD big rats showed LDs0 〉 5000 mg/kg ; acute eye irritation test showed non - irritaion ; repeated 500 mg/kg - 5000 mg/kg body weights dose tests using this solution indicated no mutagenesis effect on body cell; The maximum unobserved dosage was 〉 1000 mg/kg. And no main target organs were found to be sub - acute oral toxicity in rats. Conclusion： The disinfectant had good bactericidal effect, mild ir- ritation on mucosa, and low toxicity.
出处
《中国卫生检验杂志》
北大核心
2012年第10期2364-2366,共3页
Chinese Journal of Health Laboratory Technology
关键词
杀菌效果
皮肤表面消毒
毒理学安全性
Bactericidal effect
Skin disinfection
Toxicology security
