摘要
目的:探讨碱性成纤维细胞生长因子(Basic fibroblast growth factor,bFGF)对慢性应激模型小鼠学习记忆的影响及海马内NO含量的变化。方法:利用4周不确定应激方法建立慢性应激动物模型;每天应激前腹腔注射bFGF,持续15d;应用跳台法和避暗法观察bFGF对慢性应激小鼠学习记忆的作用;硝酸还原酶法测定海马NO的含量。结果:bFGF组小鼠学习记忆能力提高,海马NO含量降低。结论:bFGF通过降低NO含量,减轻神经元损伤改善慢性应激小鼠学习记忆能力。
Objective： To investigate the influence of bFGF on learning memory and the content of NO in hippocampus on chronic stress model in mice. Methods：Four weeks of uncertain stress was used to establish the chornic stress model. Basic fibroblast growth factor was injected daily for 15 days following stress induction. The step - down test and passive avoidance test were measured learning - memory ability. Using a nitrate reductase assay, nitric oxide levels in hippocampal homogenates were measured. Results：In bFGF group, learning - memory ability was improved;the content of nitric oxide were decreased in hippocampus. Conclusion： Trough reduing the NO content, alleviating neuronal damage, bFGF improved learning - memory ability on chronic stress model in mice.
出处
《中国民康医学》
2012年第20期2433-2434,2492,共3页
Medical Journal of Chinese People’s Health
关键词
BFGF
慢性应激
学习记忆
NO
Basic fibroblast growth factor
Chronic stress mice
l^areing - memory
Nitric oxide
