摘要
目的通过对84例奈达铂致不良反应（ADR）的病例进行分析，探讨其引起不良反应的规律和原因，为临床合理用药提供参考。方法对2004～2011年广西区药品不良反应网络管理平台提取奈达铂致ADR病例报告84例，分别从患者性别、年龄、原患疾病、用药剂量、涉及器官或系统及临床表现等方面进行统计、分析。结果84份ADR报告中，51～60岁的患者ADR发生率最高（占31．3％），ADR最为常见的临床表现为神经系统损害（占41．1％），其次为呼吸系统（占32．1％）以及皮肤及其附件（占28．6％）损害。结论应加强医务人员对奈达铂致ADR的上报意识，分析ADR的发生特点，确保临床安全，减少或避免ADR的发生。
Objective Through analysing 84 ADR cases of the nedaplatin to explore the rules and causes of adverse reactions, provide a reference for clinical rational use of drugs. Methods On the basis of the adverse drug reaction network management platform in Guangxi Zhuang Autonomous Region, 84 cases of ADR reports caused by nedaplatin from 2004 to 2011 were analyzed in terms of the gender, age, primary disease, doses, system-organs involved, clinical manifestation. Results Among 84 ADR reports, highest rate of ADR occurred in patients with 51~60 years old （31.3%）, the most common ADRs were nervous system injury（41.1%）, followed by respiratory system injury（32.1%） and skin and appendages injury（28.6%）. Conclusion Medical personnel should raise the awareness of reporting ADR of nedaplatin, analyze its characteristics, so as to ensure clinical safety, reduce or avoid the occurrence of ADR.
出处
《中国药物警戒》
2012年第11期691-693,共3页
Chinese Journal of Pharmacovigilance
关键词
奈达铂
药品不良反应
分析
nedaplatin
adverse drug reactions
analyse
