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神经酰胺代谢在细胞凋亡与自噬中的作用 被引量:3

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摘要 神经酰胺是鞘脂类的代谢产物,经从头合成及"鞘磷脂循环"形成,调节着细胞对外界不良因素的应激反应。神经酰胺的合成、代谢及信号转导在肿瘤发生、发展、耐药及抵抗放射治疗有着密切的关系。神经酰胺通过内、外在途径促进细胞发生凋亡,还能激活JNK、KSR、PKC等促进细胞凋亡。
出处 《广东医学》 CAS CSCD 北大核心 2012年第20期3175-3177,共3页 Guangdong Medical Journal
基金 广州市科技计划项目(编号:2011Y2-00019-3)
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