摘要
目的:探讨纤维蛋白原、白细胞和中性粒细胞等炎症因子对冠心病(CHD)发病的影响。方法:1487例住院患者根据经冠脉造影结果分为CHD组(1017例)和非CHD对照组(470例)。详细记录病史,体检资料,检验血常规,血脂,血糖,血浆纤维蛋白原等含量,并对结果进行比较分析。结果:与非CHD对照组比较,CHD组年龄[(58.01±11.15)岁比(60.18±11.85)岁],吸烟(34.5%比57.7%)、高血压(43.2%比66.6%)、糖尿病(11.5%比30.5%)所占比例,甘油三酯[(1.65±0.80)mmol/dl比(1.79±1.28)mmol/dl]、纤维蛋白原[(311.51±86.84)mg/dl比(362.38±94.73)mg/dl]水平和外周血白细胞计数[(6.43±4.76)109/L比(7.18±2.64)109/L]均明显增加(P<0.05),高密度脂蛋白胆固醇水平明显降低[(1.18±0.32)mmol/dl比(1.11±0.30)mmol/dl,P<0.001];中性粒细胞计数、总胆固醇和低密度脂蛋白胆固醇水平在CHD组也呈增高趋势,但两组间无显著性差异(P>0.05)。Logistic回归分析显示年龄、吸烟、高血压、糖尿病、纤维蛋白原和外周血白细胞计数对CHD均有显著影响(r=1.00～2.81,P<0.05)。结论:除吸烟、糖尿病、高血压、脂质代谢紊乱外,炎症因子纤维蛋白原、外周血白细胞水平升高也是冠心病危险因素。
Objective： To study influence of fibrinogen （Fg）, white blood cell （WBC） and neutrophil on onset of cor- onary heart disease （CHD）. Methods： According to results of coronary angiography, a total of 1487 inpatients were divided into CHD group （n = 1017） and non- CHD control group （n = 470）. Data of patients＇ history and physical examinations were recorded in detail, and blood was taken for blood routine examination, blood lipids, blood glucose, plasma Fg measurements, and the results were compared between two groups. Results： Compared with non- CHD control group, there were significant increase in age [ （58. 01 ± 11.15） years old vs. （60. 18± 11.85） years old], percentages of smokers （34. 5% vs. 57. 7%）, patients with hypertension （43.2% vs. 66.6%）, diabetes mellitus （11.5% vs. 30.5%）, levels of triglyceride E （1.65 ＋ 0.80） mmol/dl vs. （1.79 ＋ 1.28） mmol/dl], Fg V （311.51± 86.84） mg/dl vs. （362.38 ＋ 94.73） mg/dl] and peripheral WBC count [ （6.43 ＋ 4.76） 10^9/L vs. （7.18 ± 2.64） 10^9/L, P〈0.05 all], and significant decrease in level of high density lipoprotein cholestero [（1.18±0.32） mmol/ dl vs. （1.11±0.30） mmol/dl, P〈0. 001] ; Neutrophil count, levels of total cholesterol and low density lipoprotein cholesterol also increased in CHD group, but there were no significant differences between two groups （P〉0.05）. Logistic regression analysis indicated that age, smoking, hypertension, diabetes mellitus, Fg and peripheral WBC count had significant influence on CHD （r = 1.00-2.81, P〈0.05）. Conclusion： Besides smoking, diabetes mellitus, hypertension and lipid metabolic disorders, the fibrinogen and white blood cells levels increase are also risk factors of coronary heart disease.
出处
《心血管康复医学杂志》
CAS
2012年第5期486-489,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
