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自身抗体与系统性红斑狼疮孕妇的妊娠结局 被引量:3

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摘要 系统性红斑狼疮(SLE)是自身免疫介导的、以免疫性炎症为突出表现的弥漫性结缔组织病,好发于生育年龄段女性。妊娠状态有可能使SLE病情活动、恶化,同时SLE病情又能影响母胎结局。20%~35%的SLE患者会继发抗心磷脂抗体综合征,抗磷脂抗体综合征(APS)与复发性流产、胎儿生长受限、早产、死产、子痫前期的发生密切相关。抗磷脂抗体(aPL)是APS的特征性抗体,包括狼疮抗凝抗体、抗心磷脂抗体、抗β2球蛋白1抗体。抗SSA/Ro、SSB/La抗体与新生儿先天性心脏传导阻滞的发病有关。本文旨在总结这些自身抗体与SLE孕妇的妊娠结局的关系,以便指导临床。
作者 李青 狄文
出处 《实用妇产科杂志》 CAS CSCD 北大核心 2012年第9期725-728,共4页 Journal of Practical Obstetrics and Gynecology
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二级参考文献1

  • 1刘伯宁,中华妇产科杂志,1988年,23卷,9页

共引文献17

同被引文献43

二级引证文献15

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