摘要
勃起功能障碍(ED)是指不能获得或维持充分勃起以完成令人满意的性交过程。糖尿病患者中50%以上伴有ED,糖尿病性勃起功能障碍(DIED)发病机制复杂,涉及多因素。以往的研究多集中在神经病变和血管病变的影响,近来内皮细胞性及肌源性因素对ED的影响越来越受到重视。目前治疗DIED方法有多种,药物和阴茎假体植入手术在当前还是治疗DIED的标准方式,通过载体转染的基因治疗提供了另一条新的途径,但在临床应用前还需解决一些问题。
Erectile dysfunction （ED） is defined as the inability of the male to attain and/or maintain erection of penis sufficient to permit satisfactory sexual intercourse. Prevalence of impotence in diabetic men is more than 50%. The mechanism of diabetes-induced erectile dysfunction （DIED） is multifactorial, involving many factors. Previous studies focused on the influence of neuropathy and vascular lesions, but endothelial and myogenic disorders played more and more important roles in recent years. Although the treatment methods of DIED are many, drugs and the penis prosthesis implants have become the standard ways at present. Gene delivery vectors have shown a promising perspective, however, there are still some problems which need be solved further in clinical application.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2012年第10期583-588,共6页
Chinese Journal of New Drugs and Clinical Remedies
关键词
糖尿病
勃起功能障碍
治疗
diabetes mellitus
erectile dysfunction
therapy
