摘要
目的:评价我院2007-2011年抗菌药物使用量与细菌耐药性之间的关系,为临床合理有效选用抗菌药物提供依据。方法:应用用药频度(DDDs)排序对我院2007-2011年各类抗菌药物及常用品种的使用量进行统计、分析,同时对DDDs和细菌耐药率的相关性进行分析。结果:5年间,我院抗菌药物的总DDDs呈上升趋势,总增幅达5.22%;各年度总DDDs分别为192794.78、193274.70、210331.16、216185.73、203783.26;处于前5位的一直都是头孢菌素类、氟喹诺酮类、大环内酯类、青霉素类及硝基咪唑类。5年间分离得到的主要病原微生物以革兰阴性菌为主,其耐药率随DDDs的升降而波动。铜绿假单胞菌和不动杆菌属对碳青霉烯类抗生素呈现较高的耐药性。肺炎克雷伯菌对美罗培南的耐药率与其DDDs间的相关系数r=0.936(P<0.05)。结论:我院2007-2011年抗菌药物的DDDs与细菌耐药率的增加呈正相关,提示临床对抗菌药物的选用应更加规范合理,以期降低或避免细菌耐药的发生。
OBJECTIVE： To evaluate the correlation between the consumption amount of antibacterial drug and the bacterial drug resistance in our hospital from 2007 to 201, and to provide reference for the appropriate use of antibacterial drugs in clinic. METHODS： The consumption amount of various antibacterial drugs and commonly used antibacterials were analyzed statistically by DDDs order, and the correlation between DDDs of antibacterials and drug resistance was analyzed. RESULTS： The DDDs of an- tibacterial drugs in our hospital increased slightly in 5 years with the total increase rate of 5.22%. The DDDs from 2007 to 2011 were 192 794.78, 193 274.70, 210 331.16, 216 185.73, 203 783.26, respectively. Cephalosporins, fluoroquinolones, macrolides, peniciUins, nitroimidazoles took the top 5 places of DDDs. The primary pathogen isolated in 5 years was Gram-negative bacteria, and drug resistance of it fluctuated according to DDDs. Both Pseudomonas aeruginosa and acinetobacter spp. exhibited high resis- tance to carbapenems. The correlation coefficient r between the DDDs of meropenem and resistance rate of Klebsiella spp was r= 0.936（P〈0.05）. CONCLUSION： DDDs of antibacterial drugs is positively correlated to the rate of bacterial resistance in our hospi- tal during 2007--2011. The selection and use of antibacterial drug should be standardized so as to reduce or delay the incidence of bacterial resistance.
出处
《中国药房》
CAS
CSCD
2012年第42期3970-3974,共5页
China Pharmacy
关键词
抗菌药物
用药频度
耐药性
相关性
Antibacterial drug
DDDs
Drug resistance
Correlation
