摘要
AIM: To investigate age, sex, histopathology and Helicobacter pylori (H. pylori) status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients.tients submitted to upper gastroscopy at Hospital das Clinicas of Marilia, antral biopsy specimens were obtained and subjected to histopathology and H. pylori diagnosis. All patients presenting chronic gastritis (CG) and peptic ulcer (PU) disease localized in the stomach, gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study. Gastric biopsies (n = 668) positive for H. pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA ) medium (m) region mosaicism by polymerase chain reaction. Logistic regression analysis was performed to verify the association of age, sex, histopathologic alterations, H. pylori diagnosis and vacA m region mosaicism with the incidence of DU, GU and CG in patients. RESULTS: Of 1466 patients submitted to endoscopy, 1060 (72.3%) presented CG [male/female = 506/554; mean age (year) ± SD = 51.2 ± 17.81], 88 (6.0%) presented DU [male/female = 54/34; mean age (year) ± SD = 51.4 ± 17.14], and 75 (5.1%) presented GU [male/female = 54/21; mean age (year) ± SD = 51.3 ± 17.12] and were included in the comparative analysis. Sex and age showed no detectable effect on CG incidence (overall c 2 = 2.1, P = 0.3423). Sex [Odds ratios (OR) = 1.8631, P = 0.0058] but not age (OR = 0.9929, P = 0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall c 2 = 30.5, P < 0.0001). The histopathological results showed a significant contribution of ageing for both atrophy (OR = 1.0297, P < 0.0001) and intestinal metaplasia (OR = 1.0520, P < 0.0001). Presence of H. pylori was significantly associated with decreasing age (OR = 0.9827, P < 0.0001) and with the incidence of DU (OR = 3.6077, P < 0.0001). The prevalence of m1 in DU was statistically significant (OR = 2.3563, P = 0.0018) but not in CG (OR = 2.678, P = 0.0863) and GU (OR = 1.520, P = 0.2863). CONCLUSION: In our population, male gender was a risk factor for PU; ageing for GU, atrophy and metapla-sia; and H. pylori of vacA m1 genotype for DU.
AIM： To investigate age, sex, histopathology and Helicobacter pylori （H. pylori） status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients.tients submitted to upper gastroscopy at Hospital das Clinicas of Marilia, antral biopsy specimens were obtained and subjected to histopathology and H. pylori diagnosis. All patients presenting chronic gastritis （CG） and peptic ulcer （PU） disease localized in the stomach, gastric ulcer （GU） and/or duodenal ulcer （DU） were included in the study. Gastric biopsies （n = 668） positive for H. pylori by rapid urease test were investigated for vacuolating cytotoxin A （vacA ） medium （m） region mosaicism by polymerase chain reaction. Logistic regression analysis was performed to verify the association of age, sex, histopathologic alterations, H. pylori diagnosis and vacA m region mosaicism with the incidence of DU, GU and CG in patients. RESULTS： Of 1466 patients submitted to endoscopy, 1060 （72.3%） presented CG [male/female = 506/554; mean age （year） ± SD = 51.2 ± 17.81], 88 （6.0%） presented DU [male/female = 54/34; mean age （year） ± SD = 51.4 ± 17.14], and 75 （5.1%） presented GU [male/female = 54/21; mean age （year） ± SD = 51.3 ± 17.12] and were included in the comparative analysis. Sex and age showed no detectable effect on CG incidence （overall c 2 = 2.1, P = 0.3423）. Sex [Odds ratios （OR） = 1.8631, P = 0.0058] but not age （OR = 0.9929, P = 0.2699） was associated with DU and both parameters had a highly significant effect on GU （overall c 2 = 30.5, P 〈 0.0001）. The histopathological results showed a significant contribution of ageing for both atrophy （OR = 1.0297, P 〈 0.0001） and intestinal metaplasia （OR = 1.0520, P 〈 0.0001）. Presence of H. pylori was significantly associated with decreasing age （OR = 0.9827, P 〈 0.0001） and with the incidence of DU （OR = 3.6077, P 〈 0.0001）. The prevalence of m1 in DU was statistically significant （OR = 2.3563, P = 0.0018） but not in CG （OR = 2.678, P = 0.0863） and GU （OR = 1.520, P = 0.2863）. CONCLUSION： In our population, male gender was a risk factor for PU; ageing for GU, atrophy and metapla-sia; and H. pylori of vacA m1 genotype for DU.
基金
Supported by Fundaao de Amparo a Pesquisa do Estado de So Paulo (FAPESP), Research Grant 06/01223-0
Fellowship CGF 2001/14509-5
