摘要
近年来研究发现微RNA(microRNA,miRNA)与机体大部分生理、病理过程均有密切关系,如:组织的发育和分化、组织再生、病毒防御以及细胞增殖与凋亡等。miRNA在特发性肺纤维化(IPF)中的作用也日渐为研究者所重视,在IPF中有些miRNA上调(如miR-155、miR-21),有些下调(如let-7、miR-29、miR-200)。这一发现为寻找IPF治疗方法提供了一个新的突破口。本文对近年来miRNA在IPF中作用的研究进展进行了综述,并对miRNA-21、let-7d、miRNA-155、miRNA-29以及miRNA-200在肺纤维化中的作用分别进行了阐述,为研究miRNA在IPF中的作用及机制提供一定参考。
Recent studies have shown that microRNA （miRNA） is involved in most of the physiological and pathological processes including tissue development and differentiation, tissue repair, defense of virus, cellular proliferation and apoptosis. More researches find that miRNA play a critical role in idiopathic pulmonary fibrosis （IPF）. There are up-regulated miRNAs （miR-21, miR-155） as well as down-regulated ones （let-7, miR-29, miR-200） in IPF. These discoveries will make a breakthrough for seeking the therapy methods of IPF. This review summarizs recent advances on the effect of miRNAs played in IPF and a detail description of miRNA-21, let-7d, miRNA-155, miRNA-29 and miRNA-200 in lung fibrosis, providing a reference for the effect and mechanism of miRNAs in IPF.
出处
《生命的化学》
CAS
CSCD
2012年第5期419-422,共4页
Chemistry of Life
