摘要
目的:探讨静脉人工血管桥内膜增生特点及洛伐他汀可能的干预作用。方法:实验犬12只,随机分为实验组和对照组,建立颈静脉人工血管搭桥模型,以洛伐他汀作为实验干预药物,4周后取出人工血管标本,观察人工血管通畅情况,观察吻合口内膜增生形态、厚度以及新生小血管情况等,并比较两组间的差异。结果:术后4周,实验组与对照组均有3条人工血管完全闭塞,全部吻合口均可见明显内膜增生,实验组近端、远端内膜增生厚度低于对照组(P值分别为0.045,0.040),增生内膜表面可见内皮细胞覆盖,增生内膜中可见新生小血管形成,实验组近、远端内膜中新生小血管的数量均多于对照组(P值分别为0.041,0.031)。结论:4周时,吻合口内膜增生明显,同时伴有新生小血管形成,洛伐他汀可以减少内膜增生的厚度,并能够促进新生小血管的形成。
Objective： To investigate the characteristics of intimal hyperplasia and lovastatin＇s effects on canine jugular venous prosthesis bypass grafting.Methods： In the study,12 adult mistus dogs were randomly divided into 2 groups： lovastatin group and control group.All the dogs were performed with jugular venous prosthesis bypass grafting（ePTFE,6 mm in diameter,and 5 cm in length）.Four weeks later,all the 12 specimens were harvested.The patency and mural thrombus of grafts were evaluated.The characteristics of intimal hyperplasia were described and measured by HE staining and endothelial nitric oxide synthase（eNOs） immunohistochemical method.The differences between the two groups were compared.Results： Four weeks later,3 grafts with complete occlusion were found in the two groups separately.Apparent intimal hyperplasia was observed in all the grafts.The neointima of proximal and distal part in lovastatin group were thinner than in control group respectively（proximal P=0.045,distal P=0.040）.The endothelial cells were found in the surface of neointima.Newly born vessels could be found in the neointima and the new vessels were more in lovastatin group than in control group（proximal P=0.041,distal P=0.031）.Conclusion： At the end of 4 weeks,the intimal hyperplasia with neovascularization was obviously near the anastomosis.Lovastatin showed the ability to inhibit the intimal hyperplasia and promote the neovascularization.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2012年第5期783-787,共5页
Journal of Peking University:Health Sciences
关键词
人工血管
血管内膜
增生
洛伐他汀
Blood vessel prosthesis
Tunica intima
Hyperplasia
Lovastatin
