摘要
目的:了解吸入性和食入性过敏原在过敏性皮肤病发病中的作用,以及环境、饮食暴露因素与患病之间的相关性。方法:采用福克过敏原特异性IgE抗体定量检测试剂盒(免疫捕获法)检测142例过敏性皮肤病患者的血清吸入性过敏原特异性IgE(包括尘螨、艾蒿、上皮组合、霉菌组合、墙草组合、花粉组合、柳树、杨树8种)和食入性过敏原特异性IgE(包括鸡蛋、牛奶、虾、羊肉、牛肉、鲤鱼、螃蟹、小麦面粉8种),并将结果以SPSS统计软件进行分析和检验。结果:吸入物以霉菌组合的阳性率高,其中过敏性皮炎组60%,湿疹组43%,荨麻疹组46%,过敏性紫癜组71%。食入物以牛奶的阳性率高,过敏性皮炎组和湿疹组的阳性率分别为42%和56%,荨麻疹组以海鲜过敏阳性率较高,为34%。暴露因素和疾病无明显相关性。结论:过敏原IgE检测为过敏性疾病的病因诊断提供了有一定价值的依据。
Objective：To investigate the role of aeroallergen and food allergen IgE in the pathogenesis of allergen diseases and the relationship between environments,diet,exposed factors and prevalence rate in allergic skin diseases.Methods： Fooke allergen specific IgE（sIgE） antibody quantative detection kit was used to detect 142 allergen cases,including artemisia,mixture of epithelia,mixed molds,mixed botany,mixed pollens,willow,poplar,egg,milk,shrimp,mutton,beef,fish,crab,staple foods,etc.Results：Mixed molds and mixed botany were the most common allergens in the allergy dermatitis group（positive rate 60%）,eczema group（43%）,urticaria group（46%）,and allergic purpuria group（71%）.The milk revealed that it was the most common allergen in the allerge dermatitis group and eczema group（42% and 56%,respectively）.While seafood was the most common allergen in the urticaria group（34%）.There was no significant relationship between the exposure and prevalence rate.Conclusion：The detection of allergen IgE provides valuable basis for analysis of the cause in allergic disease.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2012年第5期765-769,共5页
Journal of Peking University:Health Sciences
