摘要
目的分析西咪替丁与兰索拉唑治疗消化性溃疡出血的有效性和安全性。方法所有患者均实施对症支持治疗,并选择40例患者使用西咪替丁治疗,与40例使用兰索拉唑治疗的患者比较两组胃液pH值、确定停止出血时间和疼痛消失时间,比较两组发生的并发症和统计两组的临床疗效。结果西咪替丁组治疗后胃内pH值显著低于兰索拉唑组(P<0.05);而凝血时间和疼痛消失时间均显著长于兰索拉唑组(P<0.05);西咪替丁组发生肝肾功能受损和皮疹的比率分别为22.5%和20.0%,均显著高于兰索拉唑组2.5%(P<0.05);西咪替丁组显效率高于兰索拉唑组(P<0.05)。结论兰索拉唑治疗消化性溃疡出血起效快,维持时间长,不良反应少,是一种值得临床推广的方法。
Objective To analyze the efficacy and safety of cimetidine and lansoprazole treat for peptic ulcer bleeding.Methods All patients were implemented of symptomatic and supportive,and 40 cases used cimetidine,anther 40 cases used lansoprazole,compared gastric pH,bleeding time and the pain disappeared time of the two groups,and then compared the complications and clinical efficacy.Results Intragastric pH of cimetidine treatment was significantly lower than lansoprazole group （P 0.05）;clotting time and the pain disappeared time of cimetidine treatment were significantly longer than lansoprazole group（P 0.05）;the ratio of liver and kidney dysfunction of cimetidine treatment were 22.5% and 20.0% and they were significantly higher than lansoprazole group＇ 2.5% （P 0.05）;apparent efficiency of cimetidine treatment was high than lansoprazole group（P 0.05）.Conclusion Lansoprazole treatment for peptic ulcer bleeding can quickly stop the bleeding and maintenance of a long time,as well as fewer adverse reactions,so it is worthy of clinical promotion.
出处
《中国医药科学》
2012年第20期45-46,54,共3页
China Medicine And Pharmacy
