摘要
本实验以结扎大白鼠双侧颈总动脉为脑缺血模型,测定了62只大白鼠脑组织中的血管活性肠肽(VIP)。结果发现生理盐水组脑缺血后3小时皮层和尾状核VJP含量显著低于假手术组,海马中VIP含量亦有下降趋势;丹参组与假手术组比较各脑区VIP含量无显著差异。实验结果提示VIP参与了脑缺血的病理生理过程,丹参可能具有缓解脑缺血后VIP紊乱的作用。
The levels of vasoactive intestinal peptide (VIP) in three regions of rat brain were assayed in 62 rats. In saline-treated rats, VIP levels of cerebral cortex and caudate nucleas in 3-hour group were significantly decreased in comparison with the sham-operated group. No significant difference was found between RSM-treated and sham-operated groups. The preliminary results suggest that VIP may be involved in the pathophysiologic procedures of cerebral ischemia and RSM may attenuate the dysfunction of VIP during cerebral ischemia.
出处
《军医进修学院学报》
CAS
1990年第3期250-252,共3页
Academic Journal of Pla Postgraduate Medical School
关键词
血管活性肠肽
丹参
脑缺血
疾病模型
Vasoactive intestinal peptide Salvia miltiorrhiza Cerebral ischemia Disease models,animal
