摘要
15例慢性淋巴细胞白血病(CLL)用一组单克隆抗体作免疫分型。13例为B-CLL,主要表型为CD20^+、HLA-Dr^+、SmIg^+、CD5/Em^+。2例T-CLL,1例Ts-CLL,1例为Dr^+的T-CLL。CLL骨髓中Go+G_1期细胞为91.1±2.3％(对照76.0±5.1％),S+G2M期细胞为8.9±2.3％(对照23.9±5.1％),外周血中各种周期的细胞比例与骨髓无显著差别。3例CLL在病程中发生幼淋样变。对CLL的临床过程,细胞化学,和免疫学改变作了分析。
15 cases of CLL were immunophenotyped with a panel of monoclonal antibodies. 13 cases BCLL, which was characterized by CD_20^+, HLA-Dr^+, Smlg^+, CDs^+and Em^+. 2 cases were T-CLL, one with Ts phenotype and the other with Dr^+T-CLL. The ratio of G0+G1 cells in bone marrow of CLL was 91.1±2.3%(76.0±5.1% in controls), while S+G_2M cells was 8.9±2.3% (23.9± 5.1%in controls). The ratios of various cyclic cells were similar in bone marrow and in peripheral blood. Prolymphocytoid transformation developed in late stage of 3 CLL patients. The clinical course, cytochemistry and immunologic changes in CLL are also analysed in this paper.
出处
《军医进修学院学报》
CAS
1990年第2期107-110,共4页
Academic Journal of Pla Postgraduate Medical School
关键词
单克隆抗体
免疫学技术
细胞周期
白血病
Antibodies
monoclonal Immunology technics Cell cycle Leukemia
lymphocytic
