摘要
目的评价第二代杂交捕获(HC-Ⅱ)法检测高危型人乳头瘤病毒(HR-HPV)DNA在ASC-US患者分流处理中的临床意义.方法对2005年1月至2011年7月在昆明市妇幼保健院妇科门诊患者同时行宫颈液基细胞学检查(TCT)及HC-Ⅱ法检测HR-HPV DNA,对其中宫颈细胞学结果判读为ASC-US的512例ASC-US患者进行分析和总结.结果 512例ASC-US患者中HR-HPV DNA阳性342例,占66.79%.HR-HPVDNA阳性对CINⅡ及以上病变检出的敏感性为92.65%,特异性为37.16%.对CINⅡ及以上者的阴性预测值为97.06%.结论 HC-Ⅱ法检测HR-HPV DNA在ASC-US患者分流管理中有意义.对HR-HPV DNA阳性的患者需行阴道镜检查.
Objective To evaluate the clinical significance of detecting high risk HPV DNA with hybrid capture Ⅱ technology in screening patients with atypical squamous cells of undetermined significance（ASCUS）.Methods From January 2005 to July 2011,the patients were evaluated by using liquid-based thin-layer cytology technique（TCT） in combination with a high-risk HPV-DNA test（hybrid capture 2）,in the Gynecology Outpatient department in Maternal and Child Health Hospital of Kunming.A total of 512 patients with a diagnosis of ASCUS were selected for analysis and summary.Results The number of patients with positive HR-HPV DNA was 342 in the 512 selected patients,accounted for 66.79%.HR-HPV DNA positive for CIN Ⅱ and the more bad lesion detection sensitivity was 92.65%,Specificity was 37.16%.Negative predictive rate of CIN II and the more bad lesion detection was 97.06%.Conclusions Dectecting HR-HPV DNA with HC-Ⅱ is meaningful in screening patients with ASCUS.The patients with positive HR-HPV DNA need to be inspected with colposcopy.
出处
《昆明医科大学学报》
CAS
2012年第8期70-72,共3页
Journal of Kunming Medical University
