摘要
目的:优化延胡索乙素凝胶剂的处方配比。方法:选取卡波姆、氮酮、丙二醇、甘油的用量为考察因素,以24 h累积渗透量为指标,采用正交设计法优选延胡索乙素凝胶处方,考察凝胶的体外释药性能。结果:最佳处方为延胡索乙素1%,卡波姆-940 0.5%,氮酮3%,丙二醇15%,甘油10%。结论:该凝胶剂配方合理,制备工艺简单易行,体外渗透符合零级动力学方程。
Objective： To optimize prescription ratio of tetrahydropalmatine gel. Method： With 24 h accumulative permeation amount as index, the amount of carbomer, azone, propylene glycol, glycerine was chosen as investigating factors, prescription of tetrahydropalmatine gel was optimized by orthogonal design, and to examine in vitro drug release property of this gel. Result： Optimum formulation contained 1% tetrahydropalmatine, 0.5% carbomer-940, 3% azone, 15% propylene glycol, i0% glycerol. Conclusion： This optimized formulation was reasonable, preparation technology was stable and simple, its in vitro penetration was in line with zero order kinetic equation.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第20期31-33,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
贵州省中药现代化专项(黔科合中药字[2011]5082号)
关键词
延胡索乙素
凝胶剂
正交设计
tetrahydropalmatine
gel
orthogonal design
