摘要
目的探讨2型糖尿病(T2DM)与骨质疏松的指标变化观察。方法将60例T2DM患者根据骨密度测定结果分为骨质疏松组(A组)27例和非骨质疏松组(B组)33例,并与正常健康人15例(正常组)作对照。3组均行常规治疗,在治疗第1、2、6周检测骨密度(BMD)及血清骨钙素(BGP)、空腹胰岛素(FINS)变化情况。结果 A、B组第1、2周BGP、BMD及FINS均明显低于正常组(P<0.05)。A组治疗后第6周BGP和BMD水平高于治疗后第1、2周,且第2周高于第1周,差异均有统计学意义(P<0.05);A组治疗后第1周BGP和BMD水平低于B组(P<0.05)。A、B组治疗后6周FINS水平高于治疗后第1、2周,且第2周高于第1周,差异均有统计学意义(P<0.05)。结论 T2DM患者BMD、BGP及FINS水平变化与骨质疏松关系密切,密切监测其变化有积极的临床意义。
Objective To explore the related index chang observation of type 2 diabetes mellitus（T2DM） induced osteoporosis. Methods 60 eases patients with T2DM according to bone mineral density results were divided into osteoporosis group（ A group ,27 eases） and non-osteoporosis group（ B group ,33 cases）. 15 cases of normal healthy people was selected as normal group. 3 groups underwent conventional treatment. Detected the bone mineral density（BMD） and serum calcium prime （BGP） , fasting insulin （FINS） changes in the first, second and six week after the treatment. Results The BGP, BMD and FINS of A, B groups in the first and second week were significantly lower than those of normal group ;The BGP and BMD level in the sixth week after treatment of A group was higher than those in the first and second week after treatment, the second week was higher than the first week, the difference were statistically significant（ P 〈 0.05 ）. The BGP and BMD level of A group was lower than B group in the first week（ P 〈 0.05 ）. The FINS level of A group and B group in the sixth week were higher than that in the first and second week, the second week was higher than the first week, the difference were statistically significant（ P 〈 0.05 ）. Condusion The changes of BMD, BGP and FINS are closely connect with osteoporosis, so it is clinical significance to observe the change of them.
出处
《临床合理用药杂志》
2012年第31期48-49,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
糖尿病
2型
骨质疏松
指标
Diabetes mellitus, type 2
Osteoporosis
Index
