摘要
目的探讨骨代谢标志物血清骨钙素(bone gla protein,BGP)、骨特异性碱性磷酸酶(bone alkalin phosphatase,BALP)和抗酒石酸盐酸性磷酸酶异构体5b(tartrate-resistant acid phosphatase 5b,TRACP-5b)在老年骨质疏松性骨折病人中的检测水平及临床意义。方法选择2012年7月至2015年7月我院骨科收治的90例(男45例,女45例)老年骨质疏松合并骨折病人作为试验组,选取90例(男45例,女45例)老年骨质疏松未合并骨折病人作为对照组。2组分别进行骨密度(bone mineral density,BMD)、BGP、BALP及TRACP-5b水平的测定并比较。结果试验组病人的BMD明显低于对照组,BGP、BALP、TRACP-5b水平均明显高于对照组,差异均有统计学意义(P<0.05)。采用Pearson相关分析对2组老年骨质疏松病人BMD与骨代谢标志物进行相关性分析,结果显示BMD与BGP、BALP、TRACP-5b均呈负相关(P<0.05)。结论老年骨质疏松性骨折病人BMD与血清BGP、BALP、TRACP-5b水平呈负相关。这些指标有助于临床医生鉴别易骨折的病人,同时可尽早干预骨折后的骨吸收和骨形成,从而防止骨折的再次发生。
Objective To investigate the clinical significance of the levels of bone Gla protein（ BGP）,bone alkalin phosphatase（ BALP）,tartrate-resistant acid phosphatase 5b（ TRACP-5b） in the elderly patients with osteoporotic fracture. Methods Ninety cases of elderly patients（ 45 males and 45females） with osteoporotic fractures and 90 cases of elderly osteoporosis patients（ 45 males and 45females） without fractures in our hospital from July 2012 to July 2015 were selected as case group and control group respectively. The levels of bone mineral density（ BMD）,BGP,BALP,TRACP-5b were determined and compared between two groups. Results The level of BMD in case group was significantly lower compared with the control group（ P〈0. 05）,and the levels of BGP,BALP,TRACP-5b were significantly higher compared with the control group（ P〈0. 05）. The level of BMD of the two groups was negatively correlated with BGP,BALP,TRACP-5b（ P〈0. 05）. Conclusions There is a correlation between BMD and BGP,BALP,TRACP-5b in elderly patients with osteoporotic fracture. The levels of BGP,BALP,TRACP-5b help to identify the patients who are easy to suffer from fracture,and so as to prevent re-fractures.
作者
黄泳标
卓海燕
朱建国
HUANG Yong-biao ZHU Jian-guo ZHUO Hai-yan(Department of Orthopedics, Geriatric Hospital of Fujian Province, Fuzhou 350003, China Department of Liver Disease, Infectious Disease Hospital of Fuzhou City, Fuzhou 350025, China)
出处
《实用老年医学》
CAS
2017年第3期237-239,共3页
Practical Geriatrics
