摘要
异钩藤碱(Isorhy),钩藤碱(Rhy)和维拉帕米(Ver)对KCl,CaCl_2和NA所致的兔胸主动脉条收缩呈非竞争性拮抗作用,Isorhy与Rhy的作用弱于Ver。三药对NA依赖Ca_(2+)性收缩均有明显抑制作用,但Isorhy与后两药不同,尚能抑制NA依赖外Ca^(2+)性收缩。本文提示Isorhy与Rhy和Ver相似,能阻断细胞膜上的PDC。此外。Isorhy松驰兔胸主动脉条的作用亦可能与阻断ROC有关。
The effects of isorhynchophylline(Isorhy) have been examined using the isolated rabbit aortic strip stimulated with either potassium or noradrenaline(NA). Rhynchophylline(Rhy) and verapamil (Ver) were used reference compounds. Isorhy, Rhy as well al Ver shified the KCl, CaCl_2 and NA dose—response curves to right in a non—parallel fashion, and decreased the maximal response, showing noncompetitive antagonism Isorhy and Rhy were less potent in dilating the aortic strip than Ve the compounds including Isorhy, Rhy and Ver obviously inhibited the intracellular Ca^(2+)—dependent component of NA—induced contraction of the aorta,but only Isorhy decreased the extxacelluular Ca—dependent component of contraction in same dose with Rhy and Ver. We conclude that Isorhy, like Rhy and Vre, acts by inhiditing the depolarisation—induced influx of calcium ions into the vascular smooth muscle, and may, in addition, possess some blocking activity on the receptor operated calcium channel.
出处
《合肥医学院学报》
1990年第2期16-19,共4页
Journal of Zunyi Medical University
关键词
异钩藤碱
胸主动脉
药理学
钩藤碱
isorhynchophylline
rhynchophylline
verapanil
aorta
calcium channel
