摘要
本文对 30 0名早期自然流产患者的 314例 (14名两次流产 )绒毛标本的染色体进行分析 ,检出异常核型 130例 ,检出率 41 40 % ,涉及的异常染色体有 1、2、3、4、6、7、8、9、10、11、13、14、15、16、18、2 0、2 1、2 2、X、Y。异常类型有 :常染色体三体、双重三体、性染色体三体、性染色体单体、三倍体、四倍体、嵌合体、常染色体结构异常等。并对流产儿染色体异常的再现风险及流产次数和流产儿性别与染色体异常的关系以及流产儿染色体结构异常与双亲染色体相关性等问题进行了讨论。结果表明 :流产儿染色体异常是导致早期自然流产的主要原因之一 ,开展自然流产儿染色体的研究 ,对自然流产的病因、诊断与再孕及选择合理的治疗有重要的临床指导意义。
chorionic villus samples from 300 women with early spontaneous abortion,of whom there were 14 women with two times of abortion,were collected for chromosome study.Abnormalities were found in 130 samples with detective rate of 41.4%.Abnormal chromosomes induded 1,2,3,4,6,7,8,9,10,11,13,14,15,16,18,20,21,22,X,Y and abnormal Karyotypes were antosomal triploids,double triploids.Sexual chromosome triploids sexual chromosome monoploids,trpolids,tetraploids,mosaics and chromosome structural aberrations,et al.Recurrent risk of chromosome abnormalities,relation between the number,the sex of abortion fetus and the chromosome abnernalities,and association with chromosome structural aberration of abortive fetus and parent chromosome were also studied.Based on these observations ,we conclude that chromosome abonrmalities are one of the most important factors and taht chromosome study of abortive samples plays a great rele is deteeting the cause.Dignosis and treatment of spontaneous abortion.
出处
《中国优生与遗传杂志》
2000年第3期48-50,共3页
Chinese Journal of Birth Health & Heredity
关键词
早期自然流产
绒毛
染色体异常
Early spontaneous abortion, Chorionic villus, Chromosome abnormality
