摘要
选择3-(2-氯-4-三氟甲基苯氧基)苯甲酸为起始原料,经酰氯化,再与乙醇反应成酯,然后和水合肼反应,最后与芳香醛缩合,合成了10个未见文献报道的3-(2-氯-4-三氟甲基苯氧基)苯甲酰腙4.通过IR,1H NMR,EI-MS,元素分析等方法对所合成的化合物进行了结构表征.代表化合物4-氯苯亚甲基-3-(2-氯-4-三氟甲基苯氧基)苯甲酰腙(4f)经单晶X衍射证实了结构.并初步测定了所合成化合物的杀菌和除草活性.结果表明:部分测试化合物在50 mg/L浓度下对水稻纹枯菌和黄瓜灰霉菌具有优良的抑制效果,在100 mg/L浓度下对油菜和稗草的根显示一定的抑制效果.
A series of new substituted benzaldehyde(or 2-furaldehyde)3-(2-chloro-4-trifluoromethyl)phenoxy benzoylhy-drazones 4 have been designed and synthesized by the reactions of substituted aldehydes with intermediate 3 in 64%-89%yields.The structures of compounds 4 have been confirmed by IH NMR,IR,El-MS and elemental analyses.The structure of 4-chloro-benzaldehyde 3-(2-chloro-4-trifluoromethyl)phenoxy benzoylhydrazone(4f)has been determined by X-ray single crystal diffraction.The results of preliminary bioassay indicated that some compounds possess good fungicidal activities against Rhizoctonia solani and Botrytis cinereapers at a dosage of 50 mg/L and moderate herbicidal activity against the roots of rape and barnyard grass at 100 mg/L.
作者
刘建超
崔泽平
贺红武
Liu Jianchao;Cui Zeping;He Hongwu(College of Chemistry,Central China Normal University,Wuhan 430079)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2012年第10期1925-1929,共5页
Chinese Journal of Organic Chemistry
基金
国家重点基础研究发展规划(973计划)(No.2010CB126100)
国家自然科学基金(Nos.20372023,20772042)资助项目
关键词
苯甲醛
苯甲酰腙
杀菌活性
除草活性
benzaldehyde
benzoylhydrazone
fungicidal activity
herbicidal activity
