摘要
自噬是细胞利用细胞内溶酶体清除过量或受损的长半衰期蛋白质及细胞器的现象。自噬可通过营养剥夺适应,清除细胞内蛋白质及微细胞器等生理及病理学作用和再利用细胞废物,以维持内环境稳定、参与生长发育和疾病的发生及发展。研究发现,自噬参与了心肌肥厚、心室重构、心肌缺血/再灌注损伤等多种心血管疾病病的理生理过程。本文主要阐述自噬在正常心脏及各种常见心脏疾病中作用的研究进展,并初步探讨可能的治疗新靶点。
Autophagy is a phenomenon in which the cell degrades its own components such as bulk impaired long-lived proteins and organelles. It is a lysosomal degradation pathway essential for survival, differentiation, development and homeostasis. Recent studies have demonstrated a variety of physiological and pathophysiological roles in autophagy, for example, adaptation to nutrient deprivation and intracellular clearance of protein and organelles. Autophagy plays an important pathophysiological role in cardiovascular diseases including cardiac will summarize the effects new therapeutic targets. hypertrophy, ventricular remodeling and ischemia/reperfusion. In this review we of autophagy in normal heart and cardiovascular diseases and probe into possible
出处
《心脏杂志》
CAS
2012年第5期655-657,共3页
Chinese Heart Journal
基金
高等学校博士学科点专项研究基金项目资助(200802260006)
国家自然科学基金项目资助(30872387)
