摘要
目的:研究奥扎格雷钠(sodium ozagrel,S-OZA)对垂体后叶素(pituitrin,PIT)所致大鼠心肌缺血模型的保护作用及机制。方法:采用PIT建立大鼠心肌缺血模型,观察S-OZA对大鼠心电图(ECG)、血清超氧化物歧化酶(SOD)、丙二醛(MDA)水平及血小板因子4(PF4)的影响。结果:S-OZA可抑制PIT引起的T波改变,降低血清MDA及PF4的水平,升高SOD的水平。结论:S-OZA对垂体后叶素所致大鼠缺血心肌具有一定的保护作用,其机制与其抗氧化、抗PF4等有关。
AIM： To investigate the effects of sodium ozagrel on vasopressin-induced myocardial ischemia and its mechanisms. METHODS： Myocardial ischemia was induced by vasopressin injection in rats. The effects of sodium ozagrel on ECG, malondialdehyde （MDA） level, superoxide dismutase （SOD） activity and PF4 in sera were observed. RESULTS： Sodium ozagrel significantly inhibited the changes of T-wave, lowered the level of MDA, increased SOD level and decreased the PF4 level in sera of rats with myocardial ischemia. CONCLUSION： Sodium ozagrel has some type of protective effect on vasopressininduced myocardial ischemia, possibly through its effects on antioxidant and antiplatelet factor PF4.
出处
《心脏杂志》
CAS
2012年第5期588-590,共3页
Chinese Heart Journal
