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丹皮酚对心肌梗死大鼠脂联素表达的影响 被引量：2

Effect of Paeonol on Adiponectin Expression in Rats of Myocardial Infarction
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摘要 目的观察丹皮酚对大鼠心肌梗死后脂联素表达的影响及意义。方法建立大鼠心肌梗死模型,随机分为对照组、MI组、Pae干预组。采用TTC染色法检测大鼠梗死心肌面积,ELISA法检测血浆脂联素浓度,免疫组化法检测心肌组织脂联素表达,Tunnel法检测凋亡心肌细胞。结果 Pae干预组血浆肌心肌组织脂联素分泌均增加,大鼠心肌梗死面积减少,心肌凋亡减轻。结论丹皮酚干预可以减轻大鼠心肌梗死面积及心肌凋亡,其机制可能与增加脂联素表达有关,对今后指导临床用药有重要意义。 Objective To observe the effect of Paeonol on the expression of adiponectin in myocardial infarction rats. Methods Rat MI model were made and randomly divided into control group, MI group and Pae group. Rat myocardial infarction area was detected by TTC staining method, and the expression of adiponectin was examined by ELISA and immunodhistochemistrry while the apoptosis of myocardial cells was examined by Tunnel method. Results The expression of adiponectin was significantly upregulated in ischemic area in Pae group compared with other groups, while myocardial infarct size and myocardial cells apoptosis reduced. Coulusion Paeonol intervention on rat myocardial infarction has a protective effect, and its mechanism may be related to increased adiponectin expression, so it has important significance to guide clinical medication.
作者 翟昌林 黎莉 张运
机构地区 浙江省桐乡市第一人民医院心内科 山东大学齐鲁医院卫生部心血管重构与功能研究重点实验室
出处 《医学研究杂志》 2012年第9期77-79,共3页 Journal of Medical Research
基金 嘉兴市科技计划项目(2010AY1167) 桐乡市重点科技计划项目(201003108)
关键词 丹皮酚 心肌梗死 脂联素 Paeonol Myocardial infarction Adiponectin
分类号 R540.45 [医药卫生—心血管疾病]
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参考文献9

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同被引文献48

  • 1董劭壮,赵水平,吴智鸿,阳军,胡松,聂赛.姜黄素对兔皮下脂肪细胞脂联素分泌的影响[J].医学临床研究,2007,24(8):1297-1300. 被引量：4
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  • 5Kizer JR, Arnold AM, Benkeser D, et al. Total and high-molecular- weight adiponectin and risk of incident diabetes in older people[J]. Diabetes care ,2012,35 (2) : 415-423.
  • 6Meyer L,Ciaraldi T,Henry R,et al. Adipose tissue depot and cell size dependency of adiponectin synthesis and secretion in human obesity [J]. Adipocyte,2013,4(2) : 217-226.
  • 7Dadson K, Liu Y,Sweeney G. Adiponectin action: a combination of endocrine and autocrine/paracrine effects [J]. Front Endocrin, 2011.
  • 8Yuchang F,Nanlan L,Richard L,et al. Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation [ J ]. Lipid Res,2005,46(7) : 1369-1379.
  • 9Gao H,Fall T,Van Dam RM,et al. Evidence of a Causal Relationship Between Adiponectin Levels and Insulin Sensitivity A Mendelian Randomization Study[J]. Diabetes,2013,62(4) :1338-1344.
  • 10Seino Y, Hirose H, Saito I,et al. High-molecular-weight adiponectin is a predictor of progression to metabolic syndrome : a population-based 6- year follow-up study in Japanese men[ J]. Metabolism,2009,58 (3) : 355-360.

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医学研究杂志
2012年 第9期

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