摘要
目的检测子宫内膜癌患者血清脂联素水平及胰岛素抵抗指数，探讨其临床意义及相关性。方法检测2009年9月至2011年7月在广州市第一人民医院治疗的35例子宫内膜癌患者（分为A1组：初诊子宫内膜癌未绝经组20例，A2组：初诊子宫内膜癌绝经组15例）和同期门诊体检妇女30例（对照组）的血清脂联素、空腹胰岛素和空腹血糖水平，以稳态模型评估法计算胰岛素抵抗指数（HOMA—IR）。结果Al组患者血清脂联素水平下降、HOMA—IR升高，分别为（6．7±1．1）ng／L、3．5±1．8，分别与A2组[分别为（9．2±1．0）ng／L、2．9±1．0]、对照组[分别为（10．0±1．4）ng／L、1．1±0．7]比较，差异均有统计学意义（P〈0．05）；A2组与对照组比较，差异无统计学意义（P〉0．05）；且脂联素水平越低，HOMA—IR越高，两者呈明显负相关（r=-0．389，P〈0．05）。结论子宫内膜癌未绝经患者脂联素水平降低且胰岛素抵抗，促进了子宫内膜癌发病，是其发病的危险因素。
Objective To explore changes of serum adiponectin and insulin resistance in patients with endometria] cancer and to evaluate the clinical significance and correlation. Methods The serum levels of adiponectin and fasting insulin were determined by ELISA, electro-chemilluminometry and radioimmunoassay in 35 patients with endometrial cancer [ all patients divided into two groups, A1 group belonged to without postmenopausal when first visiting （ n = 20）, A2 group belonged to postmenopausal when first visiting （ n = 15 ） ] and 30 cases of health control. The result of homeostasis model assessment-insulin resistance （HOMA-IR） index was calculated. Results The levels of adiponectin in A1 group was lower than that of health control group [（6.7 ±1.1） versus （10.0±1.4） ng/L, P 〈0.05], and HOMA-IR was higher than that of health control group （ 3.5 ± 1.8 versus 1.1± 0. 7, P 〈 0. 05 ）. While there were not significant difference between A2 group and health control group （ P 〉 0.05 ） . Adiponectin and insulin resistance was negatively correlated （ r = - 0. 389, P 〈 0. 05 ）. Conclusion Adiponectin reducing and insulin resistance in reproductive age patients may he the independent factors to promote endometrial cancers.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2012年第9期672-675,共4页
Chinese Journal of Obstetrics and Gynecology
基金
广东省科技计划（20108080702011）
