摘要
目的探讨术前动脉化疗栓塞对膀胱癌组织p53蛋白表达的影响及临床意义。方法对50例化疗栓塞前后的膀胱癌肿瘤组织,应用免疫组织化学方法测定p53蛋白的表达,并分析p53蛋白与膀胱癌病理分级、临床分期以及预后的关系。结果化疗栓塞前高分级、浸润性膀胱癌p53蛋白阳性表达率高于低分级、非浸润性膀胱癌,差异均有统计学意义(P<0.05);化疗栓塞后p53降低程度随着肿瘤的病理分级、临床分期的升高而增加,化疗栓塞前后p53中高度阳性表达率分别为64.0%、30.0%,差异有统计学意义(P<0.01);化疗栓塞前后高分级和浸润性膀胱癌组织中p53蛋白中高度阳性表达水平差异均有统计学意义(P<0.01)。经随访19.8月,总生存率为88.0%,复发率为18.0%(9/50),术后生存率与p53蛋白阳性表达强度间差异在化疗栓塞前无统计学意义(P>0.05),但在化疗栓塞后有统计学意义(P<0.05),而复发率与化疗栓塞前后p53蛋白阳性表达强度间差异均有统计学意义(P<0.05)。结论 p53表达可作为膀胱癌恶性程度判断的预后估计的指标,术前动脉化疗栓塞可以明显降低膀胱癌p53表达,调节膀胱癌的分化程度,降低复发率,提高生存率。
Objective To investigate the influence and clinical significance of preoperative arterial chemoembolization on the expression of p53 in bladder cancer tissue.Methods Before and after chemoembolization of therapy,the expression of p53 in bladder cancer tissues of 50 patients was examined by immunohistochemical staining,respectively.The relation of p53 expression to the pathological grade,clinical stage and prognosis was evaluated clinically.Results The positive rate of p53 expression in high-grade and invasive bladder cancer tissues was significantly higher than that in low-grade and non-invasive bladder cancer tissues（P0.05）.The reduction of p53 expression after arterial chemoembolization increased with the pathological grade and clinical stage ascending.Moderate and highly positive rates of p53 expression in the tissues of bladder cancer were 64.0%and 30.0%,respectively（P0.01）.Both of moderate and high positive expressions of p53 differed significantly in the two stages before and after chemoembolization（P0.01）.The patients were followed up for 19.8 months,the overall survival rate（OS） was 88.0% and the recurrent rate was 18.0%（9/50）.There was no statistical significance between survival rate before chemoembolization and the positive expression rate of p53（P0.05）,but there was statistical significance between survival rate after chemoembolization and the positive expression rate of p53（P0.01）.Recurrent rate was positively correlated with the positive expression rate of p53 before or after chemoembolization.Conclusions p53 expression can be used as a predictive factor for prognosis of bladder cancer.Preoperative arterial chemoembolization can decrease the expression of p53,downgrade the bladder cancer,decrease the recurrent rate and improve the survival rate.
出处
《实用肿瘤杂志》
CAS
2012年第5期486-489,共4页
Journal of Practical Oncology
关键词
膀胱肿瘤
蛋白质P53
化学栓塞
治疗性
免疫组织化学
预后
bladder neoplasms
protein p53
chemoemholization
therapeutic
immunohistochemistry
prognosis
