摘要
目的研究术前腹壁下动脉插管化疗对膀胱移行细胞癌P53表达的影响及临床意义。方法动脉化疗组60例术前盆腔区域化了一个疗程,再行开放手术;单纯手术对照组60例单纯行开放手术。采集肿瘤标本,行P53的免疫组织化学染色,检测癌基因蛋白的表达,同时对病人随访。结果对照组P53阳性率T1期为5.6%,T2-T3期为88.1%(P<0.01);T2-T3期P53阳性率术前动脉化疗组为25.6%,对照组为88.1%,(P<0.05);T1期P53阳性率术前动脉化疗组为5.8%,对照组为5.6%(P>0.05)。对照组术后三年复发率为16.7%,术前动脉化疗组三年复发率为7.0%,(P<0.05)。T2-T3期术前动脉化疗组5年生存率为69.8%,术后中位生存时间为51个月,对照组5年生存率为66.7%,术后中位生存时间为42个月,(P<0.05)。结论术前动脉化疗对T1期膀胱移行细胞癌P53表达无明显影响,可以降低T2-T3期P53表达,提高膀胱癌患者术后中位生存时间、降低复发率,可作为治疗浸润性膀胱癌的必要手段之一。
Objective To study the influence and clinical significance of preoperative arteria epigastria inferior cannula chemotherapy on p53 expression in transitional cell carcinoma of bladder.Methods 60 patients in arterial chemotherapy group made a course of chemotherapy preoperatively at pelvic cavity region, then they were open operated,60 patients in single-operation group only operated. We celleeted the tumorous samples,made the immunohistochemistry of p53,deteeted the expression of oncogene protein, at the same time followed-up these patients. Results In the control group the positive rate of p53 expression was 5.6% at T1 stage, at T2 - 3 stage the positive rate was 88.1% （ P 〈 0.01 ） o In the preoperative arterial chemotherapy rgoup the positive rate of p53 expression was 25.6% at T2- 3 stage, the positive rate was 88.1% （P 〈 0.05） in control group. In the preoperative arterial chemotherapy group the positive rate of p53 expression was 5.8% at T1 stage,while it was 5.6% in control group （ P 〉 0.05） .The recurrence rate of three years after operation was 16.7% in control group,in the preoperative arterial chemotherapy group the recurrence rate after three years operation was 7.0% （ P 〈 0.05）. In the preoperative arterial chemotherapy group the five-years survival rate was 69.8 %, the middle survival time postoperatively was 51 months. In control group he five-years survival rate was 66.7 %, the middle survival time postoperatively was 42 months （ P 〈 0.05）. Conclusion Preoperative arterial chemotherapy have no obvious effect the expression of p53 on transitional cell carcinoma of bladder at T1 stage,but can decrease the expression of p53 at T2- 3 stage, thus can increase the middle survival time of bladder carcinoma postoperativly, deerease the recurrence rate. Therefore, preoperative arterial chemotherapy can made one of essential means treatment of invasion bladder carcinoma.
出处
《中国实验诊断学》
2008年第3期337-339,共3页
Chinese Journal of Laboratory Diagnosis
基金
黑龙江省自然科学基金资金项目
编号为NO.D00-32
关键词
膀胱移行细胞癌
术前动脉化疗
P53
临床意义
transitional cell carcinoma of bladder
preoperative afiterial chemotherapy
p53 clinical significance
