摘要
目的合成托吡酯并对工艺进行研究。方法以D-果糖为起始原料,在浓硫酸的催化下,与丙酮缩合生成双丙酮果糖,再同氯磺酸异氰酸酯反应采用"一锅法"制备,得到托吡酯。结果本工艺总收率为43.3%。结论工艺改进后,简化了操作过程,提高了托吡酯的收率。
Objective To synthesize topiramate and research the synthetic process. Methods Catalyzed by concentrated sulfuric acid, D-fructopyranose was used as the initial raw material, then condensation of D-fructopyranose with acetone to synthesize 2,3,4,5-bis-O-（1-methylethylidene）-D-fructopyranose. The topiramate was produced by reaction between 2,3,4,5-bis-O-（1methylethylidene）-D-fructopyranose and chlorosulfonyl isocyanate via one pot method. Results The total yield by the synthetic process was 43.3%. Conclusion After the process improvement, the operating process is simplified and the yield of topiramate is improved.
出处
《现代药物与临床》
CAS
2012年第5期449-450,共2页
Drugs & Clinic
关键词
托吡酯
D-果糖
氯磺酸异氰酸酯
合成
topiramate
D-fructopyranose
chlorosulfonyl isocyanate
synthesis
