摘要
采用 EIA、PCR技术对急、慢性丙肝患者血清标本进行乙型肝炎病毒标志物、丙型肝炎不同功能区抗体和 HBVDNA、HCVRNA检测。结果 :排除甲、戊型肝炎的急、慢性丙肝的乙肝感染率为74 .67%和 59.0 9%均以 HBc Ab和 HBs Ab为主 ,其他标志物很少出现 ,有乙肝感染的丙肝 AL T值较高。HBVDNA检出率较低 ,且与 HCVRNA极少同时检出 ;急、慢性丙肝 HCVRNA检出率有乙肝感染时明显偏低。有乙肝感染时急性丙肝中 E、NS4— 5区抗体检出率明显低于慢性丙肝和无乙肝感染的急性丙肝。认为急性丙肝易受乙肝感染 ,受乙肝感染的急性丙肝 HCV抗 E、NS4— 5区抗体的产生受到抑制 ,乙、丙肝病毒之间有相互抑制现象 ,二者重叠感染可加重肝损害 ;有
The serum samples of acute and chronic hepatitis C and the different functional antibodies and HBVDNA,HCVRNA have been tested with EIA and PCR technique The result showed that the infective rate of hepatitis B with acute and chronic hepatitis C is 74 6% and 59 09% getting of hepatitis A and E and other signs have rarely found the ALT rate of hepatitis C of patients infected with hepatitis B is quite high The HBVDNA rate tested quite lower and rarely found with HCVRNA in the same time The HCV tested rate of acute and chronic hepatitis B is obviously lower than that of the patients infected with hepatitis B Antibodies in E,NS 4—5 region when the patients have been infected with acute hepatitis C is obviously lower than those of the patients with chronic hepatitis C and without infection of hepatitis B We concluded that the patients with acute hepatitis are easily infected with hepatitis B The infection of hepatitis B also have influence on the production of antibodies in HCV E, NS region of acte hepatitis C There is interaction inhibitor between virus hepatitis B and C They may be damaged seriously if the patients have secondary infection HBVDNA have been found out mainly infected with hepatitis B
出处
《山东医药》
CAS
北大核心
2000年第12期7-10,共4页
Shandong Medical Journal
基金
本课题为山东省科委
教委计划资助项目(NO.991154206 J99K71)
