摘要
目的探讨胸内Castleman病(CD)的临床病理学特点及治疗方式。方法回顾性分析1989—2011年间我院经手术病理确诊的26例胸内CD病人的临床病理资料。结果 26例胸内CD的临床分型:局限型22例,主要表现为局部淋巴结大;多中心型4例,主要表现为胸内多部位淋巴结大伴脾大、贫血、清蛋白降低等相关实验室检查异常。组织病理分型:透明血管型21例,浆细胞型4例,混合型1例。所有胸内CD病人均行病变完整手术切除,术后随访长期生存。结论胸内CD临床诊断较为困难,最终诊断仍依赖病理组织学检查。胸内CD以临床的局限型和组织病理的透明血管型多见。无论局限型或多中心型CD,手术为其治疗首选方式。对于难以完整切除的多中心型CD,可尝试以减瘤手术为主辅以术后放化疗的综合治疗。
Objective To study the clinicopathological characteristics and therapy of intrathoracic Castleman disease （ICD）. Methods A retrospective analysis was done in 26 patients with ICD treated surgically in our hospital from 1999 to 2011, all of them were confirmed pathologically. Results Their clinical typing was： localized form （Z2 cases）, main manifestation was hyperplasia of regional lymph node; and multicentre form （four cases）, main manifestations were hyperplasia of multiple regional lymph node, accompanying by splenomegaly, anemia, and low albumen. Their histopathologic typing： hyaline vascular type （21 cases）, plasma-cell type （four cases）, and mixed type （one case）. All the patients survived after complete resection of the mass. Conclusion Clinically, it is hard to make a diagnosis of ICD, the final confirmation relies on histology. Hyaline-vascular type is commonly seen. Surgery would be the first choice for the therapy of this condition. For the tumors that are difficult to be removed completely, a cytoreductive surgery plus postoperative chemoradiation might be tried.
出处
《齐鲁医学杂志》
2012年第6期482-484,共3页
Medical Journal of Qilu
关键词
巨淋巴结增生
外科手术
临床病理学
giant lymph node hyperplasia
surgical procedures, operative
elinicopathology
