摘要
目的了解原发性胆汁性肝硬化(PBC)的临床特点。方法回顾性分析37例确诊PBC病例的临床资料。结果(1)37例中男6例,女31例,男:女为1:5,平均年龄(51.1±9.5)岁,男性确诊患者有增多趋势。(2)主要临床特征为黄疸27例(73.0%),乏力24例(占64.9%),纳差14例(37.8%),瘙痒13例(35.1%),无症状5例(13.5%),脾大16例(43.2%),腹水12例(32.4%),肝大6例(16.2%),黄色瘤3例(8.1%)。(3)实验室检查异常包括:总胆红素(TBil)升高(75.7%)、碱性磷酸酶(ALP)升高(95.6%)、!-谷氨酰转肽酶(!-GT)升高(89.2%)、天冬氨酸氨基转移酶(AST)升高83.8%、丙氨酸氨基转移酶(ALT)升高(75.7%)、总胆汁酸升高(81.1%)、甘油三酯升高(56.78%)、总胆固醇升高(35.14%)、γ球蛋白升高(67.6%)、血清IgM升高(86.5%)、IgG升高(72.9%)、IgA升高(48.7%)。抗线粒体抗体(AMA)阳性率86.49%,抗M2阳性率54.05%,抗核抗体(ANA)阳性率70.27%。(4)经常规保肝药加用熊去氧胆酸等治疗后,30例病情好转,总有效率81.08%。结论PBC多见于中年女性,近年来男性确诊病例有所增加。血清ALP、γ-GT、AST、TBil、ALT、IgM明显升高及AMA、抗M2阳性有助于诊断本病。
Objective To summarize and analysis the clinical features of 37 cases with primary bil- iary cirrhosis （PBC）. Methods Clinical data of 37 patients with PBC were reviewed. Results （1）Among the 37 patients,31 were females with a female/male ratio of 5：1 and the age range was 33 -71 years old, mean （51.1 ＋9.5 ）y. （2）The main clinical features were jaundice （73.0%）, fatigue （ 64.9% ）, poor appetite （ 37.8% ）, pruritus （ 35.1% ）, no symptoms （ 13.5% ）, splenomegaly （43.2%）, ascites （32.4%）,hepatauxe （16.2%）,xanthoma（8.1% ）o （3）Abnormities of the lab tests were high bilirubinaemia（75.7%） ,elevated ALP（95.6%）,elevated γGT（89.2%）,elevated AST（83.8%）,elevated ALT （75.7%）, high TBA level （81.1%） ,hyperγ-globulinemia （67.6%） ,hyperimmunoglobulinemia （IGM86.5%, IGG72.92%, IGA48.7%） o Positive rates of anti-mitochondrial antibody （AMA）/ AMA-M2 and antinuclear antibody （ANA）were 86.5%/54.1% and 70.3%. （4） After the treatment of regular liver-protective drugs with ursodeoxycholic acid（UDCA）,the total effective rate was 81.1%. Conclusion PBC affects females mainly and the male patients with PBC were increased. The marked increase of serum ALP,γGT,AST,BiL, ALT and IgM,and positive anti-mitochondrial antibody.were with helo to the diagnosis of PBC.
出处
《药品评价》
CAS
2007年第5期352-354,共3页
Drug Evaluation
关键词
肝硬化
胆汁性
综合分析
抗线粒体抗体
熊去氧胆酸
Liver Cirrhosis,biliary
Meta-Analysis
Anti--mitochondrial antibody
Ursodeoxycholic acid
