摘要
目的观察三联药物疗法治疗顽固性慢性咳嗽的效果,并探讨其机制。方法将210例顽固性慢性咳嗽患者分为实验组和对照组。对照组采用传统疗法,实验组则给予氯苯那敏、氨茶碱、利多卡因三联药物疗法。连用3d,观察药物安全性及比较分析两组疗效。结果所有病例均无明显的药物不良反应,生命体征平稳。实验组痊愈率及总有效率均显著高于对照组,而无效率显著低于对照组,差异均有统计学意义(P<0.01)。结论氯苯那敏、氨茶碱、利多卡因三药联用,可能起到协同作用,针对发病机制治疗,因而能快速消除变应性哮喘顽固性咳嗽症状。
Objective To observe the therapeutic effect of three drugs therapeutic alliance on refractory chronic cough,and ex plore its mechanisms. Methods 210 patients with refractory chronic cough were divided into test group（traditional remedy was giv en for consecutive three days） and control group（combined therapy of chlorphenamine,aminophylline and lidocaine,for consecutive three days）. The safety of the drugs was observed and therapeutic effect was compared and analyzed between two groups. Results No evident adverse drug reaction occurred in all eases. All subjects＇ vital sign was stable. As compared with those of control group, the healing rate and total effective rate were both significantly higher,and ineffective rate was significantly lower in test group. The differences were statistically significant（all P〈0.01）. Conclusion Combined use of three drugs（chlorphenamine,aminophylline and lidocaine） may exert synergetic effect and aim at pathogenesis; therefore, it can quickly eliminate the refractory chronic cough of atopic asthma.
出处
《重庆医学》
CAS
CSCD
北大核心
2012年第29期3072-3073,共2页
Chongqing medicine
