摘要
目的探讨N-乙酰基转移酶(N-acetyltransferase,NAT)基因多态性与老年大肠癌易感性的关系。方法采用PCR-RFLP技术对105例年龄>60岁大肠癌患者(大肠癌组)和121例体检健康者(对照组)NAT基因多态性进行检测,分析NAT基因型分布特征。结果大肠癌组基因型Wt/M2频率(58.44%)明显高于对照组(23.41%)(P<0.01);2组慢速乙酰化基因型频率差异无统计学意义(P>0.05);吸烟组NAT快速乙酰化型个体患大肠癌风险(OR=1.959,95%CI:0.870～4.410)高于不吸烟组(OR=1.674,95%CI:0.830～3.378)。结论快速乙酰化基因型Wt/M2可能是老年大肠癌发病危险因素,NAT快速乙酰化基因型与吸烟有协同作用。
Objective To investigate the relationship between polymorphism of N-acetyltransferase （NAT） gene and susceptibility to colorectal cancer in the elderly patients. Methods PCR-RFLP assay was used in 105 patients with colorectal cancer and 121 controls to determine polymorphism of NAT to analyze the genotypes of NAT. Results The frequency of genotype Wt/M2 was higher in patients with eolorectal cancer （58.44%） than that in controls（23.41%） （P〈0.01）. There was no significant difference in slow-aeetylator genotypes between patients with colorectal cancer and controls （P〉0.05）. The risk of colorectal cancer was higher in the individuals with NAT fast genotype in smoking group （OR=1.959, 95%CI： 0. 870 to 4. 410） than that in non-smoking group （OR=1. 674, 95%CI： 0. 830 to 3. 378）. Conclusion The genotype Wt/M2 may be a risk factor of colorectal cancer in elderly patients. The NAT fast genotype and smoking have asynergistic effect on colorectal cancer.
出处
《中华实用诊断与治疗杂志》
2012年第10期965-967,共3页
Journal of Chinese Practical Diagnosis and Therapy
关键词
大肠癌
N-乙酰基转移酶
多态现象
疾病易感性
Colorectal cancer
N-acetyltransferase
polymorphism
disease susceptibility
