摘要
目的:研究京尼平苷对CCl4诱导的大鼠慢性肝损伤的保护作用。方法:每周给大鼠腹腔注射2次一定体积比的CCl4豆油混悬液,连续9周,致大鼠肝纤维化。然后对肝损伤大鼠每天灌服一定剂量的京尼平苷进行治疗,连续4周,末次灌服13小时后,取血以及肝脏,对血清中的AST、ALT、AKP、NO以及肝匀浆中CuZn-SOD、GSH-Px、MDA、HYP和CAT等各项生化指标进行测定,并对肝组织进行光镜分析。结果:当京尼平苷的灌服剂量为100mg/kg时,能显著改善肝损伤大鼠血清中AST、ALT水平,提高肝组织中SOD、CAT和GSH的活力,降低肝组织中MDA的含量,并减轻组织炎症及纤维化。结论:京尼平苷对大鼠慢性肝损伤有较好的保护作用。
Objective： To study the therapeutic effects of genipeside on chronic liver injury induced by CCI4 in rats. Methods： A certain volume rate of CC14 and soybean oil suspension was fed to rats twice a week for 9 weeks, in order to build the model of chronic liver injury. And then, different doses of geniposide were fed to rats for 4 weeks every day. Twelve hours after the last administration, the index of AST, ALT, AKP, NO in serum and SOD, MDA, HYP, CAT, GSH in liver were measured. Sections stained by hematoxylin-eosin were also observed un- der light microscope. Results： The Pathological indicators of serum and liver improved, when the dose of lOOmg/kg was chose. Conclusion： Geniposide was effective in treating chronic liver injury induced by CCl4 in rats.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2012年第4期29-31,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
林业公益性行业科研专项经费项目(201204601)
关键词
京尼平苷
肝损伤
病理指标
geniposide
chronic liver injury
pathological indicators
