期刊文献+

全身骨显像联合血清PSA、fPSA及fPSA/PSA比值对前列腺癌骨转移的诊断价值 被引量:9

The diagnostic value of combining whole body bone images with serum PSA,fPSA and fPSA/PSA ratio in the diagnosis of bone metastasis in patients with prostate cancer
暂未订购
导出
摘要 目的:通过99mTc-MDP全身骨显像与血清PSA、fPSA及fPSA/PSA比值的联合检查,探讨对前列腺癌骨转移的诊断价值。方法:对90例经病理证实为前列腺癌患者及30例良性病变患者行全身骨显像。在行全身骨显像的前后1周内进行血清PSA、fPSA及fPSA/PSA比值测定。结果:90例前列腺癌患者中59例发生骨转移,占65.56%。前列腺癌骨转移患者以骨盆转移最多,其次是脊柱,胸骨最少。与良性病变患者组比较前列腺癌骨转移组、未转移组血清PSA、fPSA水平明显升高,fPSA/PSA比值明显降低(P<0.01);与未转移组比较,骨转移组血清PSA、fPSA水平明显升高,fPSA/PSA比值明显降低(P<0.01)。骨转移组中多发骨转移者血清PSA、fPSA水平明显高于单发骨转移者,多发骨转移者fPSA/PSA比值水平明显低于单发骨转移者(P<0.01)。结论:全身骨显像联合血清PSA、fPSA及fPSA/PSA比值测定,对于诊断骨转移,特别是前列腺癌发生的单发骨转移有重要的临床意义。
出处 《中国临床医学影像杂志》 CAS 2012年第9期672-674,共3页 Journal of China Clinic Medical Imaging
  • 相关文献

参考文献11

  • 1Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009[J]. CA: Cancer J Clin, 2009, 59(4): 225-249.
  • 2曹剑霞,李斌,高卉.PSA、fPSA检测和核素骨显像在前列腺癌骨转移诊断中的意义[J].放射免疫学杂志,2009,22(2):184-185. 被引量:6
  • 3Chiu JS, Wang YF, Su YC, et al. Artificial neural network to predict skeletal metastasis in patients with prostate cancer [J]. J Med Systems, 2009, 33(2): 91-t00.
  • 4Yahara J, Noguchi M, Noda S. Quantitative evaluation of bone metastases in patients with advanced prostate cancer during systemic treatment[J]. BJU Int, 2003, 92(4): 379.
  • 5Baxter AD, Coakley FV, Finlay DB, et al. The aetiology of solitaryhot spots in thy fibs on planar bone scans [J]. Nucl Med Commun, 1995, 16(10): 834-837.
  • 6谢红军,匡安仁.^(99m)TC-MDP全身骨显像165例前列腺癌骨转移的分析[J].四川医学,2005,26(11):1215-1216. 被引量:13
  • 7James L, Andrew J, Robert R, et al. NCCN Clinical Practice Guidelines in Oncology: Prostate Cancer[J]. Natl Compr Canc Net, 2011, 8(2): 162-200.
  • 8袁红纲,宋兴福,董自强.前列腺特异性抗原与前列腺疾病的研究进展[J].陕西医学杂志,2008,37(1):109-111. 被引量:3
  • 9Birtle A J, Freeman A, Masters JR, et al. Clinical features of patients who present with metastatic prostate carcinoma and serum prostate specific antigen (psa) levels<10g/mL: the "PSA negative" patients[J]. Cancer, 2003, 98(11): 2362-2367.
  • 10Mueller-lisse UG, Mueller-lisse UL, Hailer S, et al. Likehood of prostate cancer based on prostate-specific antigen density by MRI: retrospective analysis [J]. J Comput Assist Tomogr, 2002, 26(3): 432-437.

二级参考文献38

  • 1Sy WM. Serial bone scans in orchiectomized men with prostatic bone metastase. Clin Nucl Med, 1998, (6) :456.
  • 2Wymenga L, Boomsma J, Groenier K, et al. Routine bone scans in patients with prostate cancer related to serum prostate specific antigen and alkaline phosphatase. BJU Int, 2001,88(3) :226.
  • 3Marcel S, Aeilko Z, Jaap Z, et al. The value of pretreatment clinical and biochemical parameters in patients with newly diagnosed untreated prostate carcinoma and no indications for bone metastases on the bone scintigram. Eur J Nucl Med,1997,24:1215.
  • 4潘中允.前列腺癌的核素检查和治疗[A].郭应禄.前列腺增生及前列腺癌[C].北京:人民出版社,1998.188.
  • 5孙达.放射性核素骨显像[M].杭州:浙江大学出版社,2000.32-33.
  • 6王益鑫 李东.早期前列腺癌筛选[A].顾方六主编.现代前列腺病学(第1版)[M].北京:人民军医出版社,2002.361-365.
  • 7戴玉田.前列腺癌的临床表现与诊断[A].吴阶平主编.吴阶平泌尿外科学(第1版)[M].济南:山东科学技术出版社,2004.1074-1083.
  • 8周荣祥,程继义.男性泌尿生殖系统肿瘤.北京:人民卫生出版社.2001,303.
  • 9He D,Wang M,Chen X,et al, Ethnic differences in distribution of serum prostate -specific antigen:a study in a healthy Chinese male population [ J ]. Urology ,2004,63 (4) :722-726.
  • 10Chinegwundoh F,Enver M,Lee A,et al. Risk and presenting features of prostate cancer amongst African -Caribbean, South Asian and European men in North- east London [ J]. BJU Int,2006,98 (6) :1216-1220.

共引文献29

同被引文献76

引证文献9

二级引证文献49

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部