摘要
目的探讨2型糖尿病患者视觉诱发电位(pattern visual evoked potential,P-VEP)改变的特点及其与各临床因素之间的关系。方法对109例2型糖尿病患者及40例健康体检者进行P-VEP的检测,病例组按病程分为病程<5年组、5年≤病程<10年组、病程≥10年组。回顾性分析各组生化指标、肌电图等临床资料与P-VEP改变的相关性。应用SPSS统计软件进行统计学处理。结果病例组P-VEP总异常率为27.52%,病程<5年组P-VEP异常8例(20.00%),5年≤病程<10年组P-VEP异常8例(25.81%),病程≥10年组P-VEP异常14例(36.84%),各组间其异常率比较差异无统计学意义(P>0.05)。P100潜伏期的改变:病程≥10年组的P100潜伏期较对照组明显延长(P<0.05),病程<5年组、5年≤病程<10年组的P100潜伏期较对照组无明显变化(P>0.05)。P100枕中波幅改变:5年≤病程<10年组,病程≥10年组的枕中波幅较对照组明显降低(P<0.05),病程<5年组的枕中波幅较对照组无明显变化(P>0.05)。周围神经病变严重组(病变神经数>4条)的枕中波幅较周围神经病变较轻组(病变神经数≤4条)明显降低(P<0.05)。非条件Logistic逐步回归分析显示病程和糖化血红蛋白是2型糖尿病患者视力损害的相关因素。结论 P-VEP是早期发现2型糖尿病患者视神经病变的无创检测手段。病程和糖化血红蛋白是2型糖尿病患者视神经病变的相关因素。
Objective To study the characteristic of pattern visual evoked potentials（P-VEP） in patients with type 2 diabetes and the relationship between the clinical factors and P-VEP.Methods In this study,109 patients with type 2 diabetes were divided into three subgroups according to the disease duration,〈5 years group,5≤course duration 〈10 years group,≥10 years group.Patients and 40 healthy controls were analyzed retrospectively regarding clinical data,blood biochemicals,electromyography（EMG） and P-VEP changes.The results were analyzed by SPSS statistical software.Results The abnormal rate of P-VEP was 20.00% in 〈5 years group（8 cases）,25.81% in 5 ≤course duration 〈10 years group（8 cases）,and 36.84% in ≥10 years group（14 cases）,with the mean abnormal rate of 27.52%.There was no statistically significant difference among the three diabetic groups（P〉0.05）.The amplitude was lower significantly in 5≤ course duration 〈10 years group and ≥10 years group compared with the control group（both P〈0.05）.There was no significant difference in the amplitude between the two groups（P〉0.05）.The latency of P100 was longer in ≥10 years group significantly than that in the control group（P〈0.05）.There was no statistically significant difference of the P100 latency between the two groups（P〉0.05）.In the severe group（the number of diseased nerve〉4）,the amplitude was lower significantly than that in the less serious group（the number of diseased nerve≤4）（P〈0.05）.Non-conditional logistic regression analysis showed that course and glycosylated hemoglobin（HbALc） were the relevant factors of visual impairment in patients with type 2 diabetes.Conclusions P-VEP was a non-invasive method for the early detection of optic neuropathy in patients with type 2 diabetes.The course of disease and HbALc level were the relevant factors of visual impairment in patients with type 2 diabetes.
出处
《中国神经免疫学和神经病学杂志》
CAS
北大核心
2012年第5期362-365,370,共5页
Chinese Journal of Neuroimmunology and Neurology
关键词
糖尿病
2型
诱发电位
视觉
相关因素
diabetes mellitus, type 2
evoked potential, visual
relevant factors
