摘要
目的:探讨同步放化疗与序贯放化疗对局部晚期宫颈癌患者的疗效及毒副反应。方法:将80例中晚期宫颈癌患者随机分成3组,A组(放疗组)24例,B组(序贯放化疗组)33例,C组(同步放化疗组)23例,比较3组疗效及毒副反应。结果:3组间有效率差异无显著性(P>0.05),B、C组完全缓解率分别为66.67%,78.26%,与A组33.33%相比差异有显著性(P<0.05)。B组、C组3年生存率分别为54.5%、65.2%,与A组33.33%相比差异有显著性(P<0.05)。放化疗联合的骨髓抑制和胃肠道反应明显高于单纯放疗。结论:同步放化疗与序贯放化疗均能明显提高局部宫颈癌的生存率;毒副反应较重,但患者可以耐受。
Objective To investigate the efficacy and side effects of concurrent chemoradiotherapy and sequential chemoradiotheraphy for locally advanced cervical cancer. Methods 80 patients with locally advanced cervical cancer were randomized into Group A （radiotherapy alone, n = 24）, Group B （sequential chemoraditheraphy, n = 33） and Group C （concurrent chemoradiotherapy, n = 23）. The efficacy and side effects in the three groups were observed and compared. Results There were no significant differences among the three groups in the effective rate （P 〉 0.05）. The complete remission rates in Group B and C were 66.67% and 78.26%, which were significantly higher than that in Group A （33.33%） （P 〈 0.05）. The 3-year survival rates were 54.5% and 65.2%, which were also higher than that in Group A （33.3%） （P 〈 0.05）. There were more obvious side effects as digestive tract and bone marrow depression in Group B and C. Conclusion Chemoradiotherapy for locally advanced cervical cancer can significantly improve the patients＇ survival rate, but can induce more severe side effects, which the patients could tolerate.
出处
《实用医学杂志》
CAS
北大核心
2012年第18期3059-3061,共3页
The Journal of Practical Medicine
关键词
同步放化疗
序贯放化疗
局部晚期宫颈癌
Concurrent chemoradiotheraphy
Sequeutial chemoradiotheraphy
Locally advancedcervical cancer
