摘要
目的:探讨补阳还五汤治疗急性脑梗死的作用机制。方法:65例急性脑梗死患者随机分为治疗组33例和对照组32例,对照组给予常规用药,治疗组在对照组基础上给予补阳还五汤,治疗14天;对两组患者进行治疗前后的神经功能缺损程度评分,ELISA法检测治疗前后血清基质金属蛋白酶-9(MMP-9)和白细胞介素-8(IL-8)水平变化。结果:治疗组用药后神经功能缺损程度评分较对照组明显改善(P<0.05),血清MMP-9、IL-8水平均较治疗前明显下降(P<0.01),且IL-8与对照组比较差异有统计学意义(P<0.05)。结论:补阳还五汤对急性脑梗死患者神经功能的改善可能与调节血清MMP-9、IL-8水平有关。
Objective ： To explore the effect of Buyang Huanwu decoction for acute cerebral infarction. Methods ： 65 cases of acute cerebral infraction were randomly divided into the treatment group （ n=33 ） and control group （ n=32 ）. The control group received conventional medication, the treatment group was used Buyang Huanwu decoction besides the therapy of the control group. After 14 days, Neurological impairment scale were evaluated, matrix metallporotelnases-9 （ MMP-9 ） and interleukin-8 （ IL-8 ） were detected by elisa in two groups before and after treatment. Results： Treatment group neurological impairment scores improved significantly than the control group （ P〈0.05 ） .The levels of serum MMP-9, IL-8 decreased significantly than that before treatment （P〈0.01）, and IL-8 compared with the control group the difference was statistically significant （P〈0.05）. Conclusion： Buyang Huanwu decoction improvement in neurological function in acute cerebral infarction may be related to the regulation of serum MMP-9, IL-8.
出处
《辽宁中医药大学学报》
CAS
2012年第10期161-162,共2页
Journal of Liaoning University of Traditional Chinese Medicine
