摘要
目的观察亚低温对急性脑梗死(ACI)患者的临床疗效及对患者血清MMP-9水平的影响。方法 75例ACI患者随机分成亚低温治疗组(n=40)、常规治疗组(n=35)以及健康对照组(n=40)。采用ELISA法检测两组患者治疗前和治疗后24h、72h、7d、14d的血清MMP-9水平,并在治疗后14d进行临床疗效的判定。结果治疗前两组的MMP-9水平高于健康对照组(P<0.05),两组治疗后MMP-9水平均明显下降,亚低温治疗组降低较常规治疗组更明显(P<0.05)。而且亚低温治疗组临床总有效率明显高于常规治疗组(P<0.05)。结论亚低温治疗可降低急性脑梗死患者血清MMP-9水平,提高急性脑梗死患者治疗的有效率。
Objective To investigate the clinical effect of mild hypothermia for acute cerebral infaction （ACI） and its influence on the levels of matrix metalloprotenaise-9 （MMP-9） in the peripheral blood of patients with ACI. Methods 75 patients with ACI were randomly divided into group A （n=40, treated by mild hypothermia） and group B （n=35, treated by conventional treatment）. 40 health subjects were selected as the control group. Expression of MMP-9 was measured by ELISA before and 24 h, 72 h, 7 d and 14 d after treatment. The clinical effect was detected 14 days after treatment. Results The levels of MMP-9 in group A and group B before treatment were obviously higher than those in the control group （P〈0.05）. The levels were significantly decreased after treatment, and the lowering in group A was more significant than that in group B （P〈0.05）. The total effective rate in group A was significant higher than that in group B （P〈0.05）. Conclusion Mild hypothermia therapy can down-regulate the expression of MMP-9 in patients with ACI, so as to improve the efficacy of the treatment.
出处
《海南医学》
CAS
2011年第17期33-34,共2页
Hainan Medical Journal
关键词
亚低温
脑梗死
基质金属蛋白酶-9
Mild hypothermia
Cerebral infarction
Matrix metalloprotenaise-9
