摘要
目的:探讨不同银杏内酯化合物对家兔血小板聚集作用的影响。方法:进行体外实验观察不同银杏内酯化合物对由血小板活化因子(PAF)诱导的家兔血小板聚集作用的影响。结果:不同银杏内酯化合物体对PAF诱导的血小板聚集均有抑制作用,IC50在0.24～27.44μg/mL之间。结论:不同银杏内酯化合物体外对血小板聚集均有抑制作用差异明显。
Objective：To observe the effects of antinplatelet aggregation activity induced by PAF of ginkgolide compounds. Methods ： The activity of seven ginkgolide compounds had been evaluated on rabbit platelet aggregation induced by PAF in vitro, and the IC50 value were calculated. Results ： Each ginkgolides had displayed different intensity activities, the IC50 value of which were between 0.24 and 27.44 μg/mL. Conclusion ： The experiment result had indicated that the difference of antinplatelet aggregation activity induced by PAF of ginkgolide compounds was obvious due to structure difference.
出处
《辽宁中医药大学学报》
CAS
2012年第10期63-65,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
福建省科技厅资助项目(2012J05151)
关键词
银杏内酯
血小板聚集
血小板活化因子
ginkgolide
antinplatelet aggregation activity
platelet-activating factor
