摘要
目的:研究姜黄素液晶纳米粒大鼠的口服吸收。方法:采用热处理-高压匀质法制备姜黄素液晶纳米粒,利用HPLC测定血浆中姜黄素浓度,DAS 2.0软件处理数据,求算药动学参数。结果:姜黄素液晶纳米粒口服吸收符合单室模型;与原料药组相比,姜黄素液晶纳米粒口服相对生物利用度为395.56%。结论:液晶纳米粒显著提高了姜黄素的口服吸收。
OBJECTIVE To study the oral absorption of curcumin-loaded liquid crystalline nanoparticles in rats.METHODS Curcumin loaded liquid crystalline nanoparticles were prepared with the method of hot treatment and high-pressure homogenization,curcumin in plasma was determined by HPLC and the results were analyzed with Program DAS 2.0 to obtain the pharmacokinetics parameters.RESULTS The oral absorption of curcumin loaded liquid crystalline nanoparticles in rat fitted one-compartment model,and the relative bioavailability was 395.56% compared to crude CUR.CONCLUSION Liquid crystalline nanoparticles could markedly improve the oral absorption of CUR in rat.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2012年第18期1423-1426,共4页
Chinese Journal of Hospital Pharmacy
基金
山东省科技攻关项目(编号:2010GWZ20203)
关键词
姜黄素
纳米粒
生物利用度
curcumin； nanoparticle； bioavailability；
