摘要
目的:制备姜黄素脂质立方液晶纳米粒,并对其主要理化性质进行评价。方法:采用热处理高压匀质法进行制备,以载药量和包封率为指标,采用均匀设计法对处方和工艺进行优化,并考察其理化性质。结果:制得的液晶纳米粒在电镜下呈类球形,平均粒径176.1 nm,zeta电位-25.19 mV,平均载药量(1.5±0.2)%,包封率(95±1.8)%,36 h体外释放60.0%,释放方程为ln(1-Q)=-0.0251t-0.0075。结论:姜黄素脂质立方液晶纳米粒具有较高的包封率和良好的缓释作用。
Objective：To prepare curcumin-loaded lipid cubic liquid crystalline nanoparticles and evaluate its physiochemical properties.Methods：The nanoparticles were prepared using hot and high-pressure homogenization.The prescription and preparation process were optimized by uniform design with drug loading and entrapment efficiency as indexes.Results：The nanoparticles were spherical under transmission electron microscope（TEM） with average particle size of 176.1 nm,zeta potential of-25.19 mV,average drug loading of（1.5±0.2） % and entrapment efficiency of（95±1.8）%.The release equation：ln（1-Q）=-0.0251t-0.0075.The cumulative release percentage was 60% at 36 h in vitro.Conclusion：The obtained curcumin-loaded lipid cubic liquid crystalline nanoparticles shows high entrapment efficiency and good sustain release property.
出处
《中药材》
CAS
CSCD
北大核心
2012年第2期296-299,共4页
Journal of Chinese Medicinal Materials
基金
山东省科技攻关课题(2010GWZ20203)
关键词
姜黄素
脂质立方液晶纳米粒
甘油单油酸酯
体外释放
Curcumin
Lipid cubic liquid crystalline nanoparticles
Monoolein
In vitro release
