摘要
目的探讨视听觉屏蔽对特发性耳鸣患者脑内葡萄糖代谢分布的影响。方法对1例慢性特发性耳鸣患者分别在视听觉屏蔽和开放条件下进行全脑正电子发射计算机断层显像（positron emission tomography，PET）检测，通过视觉观察和统计参数图方法分析脑内葡萄糖代谢分布的差异。结果视听觉开放条件下患者双侧听觉皮层、视觉皮层的葡萄糖代谢明显增高，而在视听觉屏蔽条件下双侧听觉皮层、视觉皮层未见葡萄糖明显高代谢现象，但左侧Wernicke区出现葡萄糖代谢增高。结论慢性特发性耳鸣的产生可能与听觉皮层异常无关，Wernicke区可能在耳鸣中枢感知中起到一定的作用。
Objective To study the influence of the audio-visual block （AB） on the brain glucose metabolism of idiopathic tinnitus patients. Methods The brain positron emission tomography （PET） test was performed on one chronic idiopathic tinnitus patient under audio-visual block and non-block （NB） conditions respectively. The visual analysis and statistical parameter mapping（SPM） analysis were both used to detect the brain glucose metabolism difference under AB and NB conditions. Results Under NB conditions, significant hyperactivity was detected at auditory and visual cortex on both sides of the brain. However, this phenomenon was not shown under AB conditions. Instead, a hyperactivity of brain was presented in the left Wernicke＇s area. Conclusions The generation of chronic idiopathic tinnitus probably has no relationship with the auditory cortex abnormity. Wernicke＇s area might be involved in the central perception of tinnitus.
出处
《中华耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2012年第9期720-723,共4页
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
基金
上海市科委基金项目（08411961200）
关键词
耳鸣
正电子发射断层显像术
脑化学
视皮质
听觉皮质
Tinnitus
Positron-emission tomography
Brain chemistry
Visual cortex
Auditory cortex
