摘要
介绍了从开棺高度腐败尸体脏器中检验常见碱性药物的方法.在高度腐败及脂肪较多的脏器中加入碱性药物利多卡因、安坦、氯丙嗪、安定、氯氮平及内标物SKF_525A各5.0μg,舒乐安定、佳静安定各10.0μg,在碱性条件下用乙酸乙酯与乙醚混合液提取,经GC/NPD分析.回收率因各药的性质不同有较大差异,从20%～77.2%不等.腐败尸体脏器是明显碱性,产生的生物基质对利多卡因和安定的检验有一定干扰.
This study develops a method for analysis of basic drugs from necrogenic tissues. Basic drugs, lidocaine, benghexolum, chlorpromazine, diazepam, clozapine, internal standard of SKF525A(all of 5μg), estazdam and alprazolam (all of 10μg), are extracted from superfatted necrogenic tissues with mixture reagents of ethyl acetate and diethyl ether under basic condition, and determined by gas chromatography with nitrogenphosphorus detector (GC/NPD). Recoveries of those drugs change from 20% to 77. 2% because of different nature. Necrogenic tissue is basic, and some substances in which disturb the analysis of lidocaine and diazepam.
出处
《刑事技术》
北大核心
2000年第4期6-8,共3页
Forensic Science and Technology
