摘要
已有的研究提示肿瘤与炎症之间存在密切关系，各种炎症因素通过参与局部微环境的形成影响肿瘤发生发展。许多临床研究发现，胆囊炎症与胆囊癌存在密切联系，是影响胆囊癌发生和预后的高危因素之一，但具体机制仍未完全明嘹。一方面，胆囊炎与胆囊结石之间互为因果、互相促进是临床的共识，而后者可能是胆囊癌发生的重要影响因素。另一方面，胆囊癌患者胆汁中可以分离出的许多细菌。研究较多的主要有伤寒杆菌、螺杆菌和大肠杆菌，提示炎症与其病原体的共同作用可能是其参与胆囊癌发生发展的重要途径。另外，肿瘤局部微环境中存在许多炎性细胞（肿瘤浸润细胞），在胆囊癌发生发展中亦可能发挥不可忽视的作用。由于胆囊炎症与肿瘤的关系尚未完全揭示，没有特别针对胆囊癌的抗炎药物问世，故针对抗肿瘤的抗炎治疗在胆囊癌防治中亦未普及。但是，随着研究的深入，抗炎治疗也许会在胆囊癌的治疗中发挥越来越重要的作用。
Previous studies have suggested that vari- ous kinds of inflammatory factors can influence the formation and development of tumor cells. Researche has shown that gallbladder cancer is closely linked with local inflammation, which is a risk factor for the development of gallbladder cancer. It is widely known that cholecystitis is closely corre- lated with gallstones, and that bile obtained from patients with gallbladder cancer contains a large variety of bacteria, such as Salmonella typhi, Helicobacter, and Escherichia co- ll. It is proposed that the gallbladder may be the result of the joint action of inflammation with the bacterial flora. Similar- ly, the inflammatory ＂tumor infiltrating lymphocyte＂（TIL） can be observed in the tumor and its surrounding tissues, and may also play a role in tumor growth and metastasis. However, detailed mechanisms about the relationship be- tween inflammation and gallbladder cancer is still not clear. No specific anti-inflammatory drugs for gallbladder cancer have been developed. In the near future, antiqnflammatory drugs may play a more important role in gallbladder cancer prevention and treatment.
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2012年第9期723-726,共4页
Chinese Journal of Hepatobiliary Surgery
基金
西安交通大学医学院第一附属医院“临床医学专业七年制学生临床创新科研基金”资助项目（11ZD27）
关键词
炎症
肿瘤
胆囊癌
Inflammation
Tumor
Gallbladder cancer
