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肝硬化肝癌患者的入院血红蛋白水平对肝移植预后的影响 被引量:1

The influence of admission hemoglobin value on early postoperative lung complications in cirrhosis- associated hepatocellular carcinoma patients undergoing liver transplantation
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摘要 目的探讨入院血红蛋白值(hemoglobin,Hb)对伴肝硬化的肝细胞肝癌患者肝移植术后早期恢复的影响。方法回顾性分析广西医科大学第一附属医院2001年4月至2010年2月连续施行的100例肝移植患者的临床情况。肝移植术后45例患者出现肺部并发症。用Bivariate相关分析分析人院Hb和术后肺部并发症的关系,找出影响术后肺部并发症的入院Hh的阈值,并以阈值为界,比较两组患者围手术期的27项临床参数。结果入院Hb≤100g/L是影响肝移植术后肺部并发症的阈值。Hb≤100g/L组患者的术后肛门排气时和术后ICU监护时间均比Hb〉100g/L组长.且术血气分析情况较Hb〉100s/L组差。结论入院血红蛋白值能够影响伴肝硬化的肝细胞肝癌患者肝移植术后早期的恢复。 Objective To investigate the clinical significance of admission hemoglobin (Hb) value for posttransplantation early respiratory complications in cirrhotic hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT). Methods Between April 2001 and February 2010, the medical record of 100 consecutive liver recipients at First Affiliated Hospital of Guangxi Medial University were retrospectively reviewed. Pulmonary complications developed in 45 patients after LT. Using bivariate correlation analysis between the admission Hb value and pulmonary complications screened for the threshold value of admission Hb value affecting early-phase pulmonary complications. According to the threshold value of admission Hb, LT recipients could be divided into two groups. Twenty-seven peri-operative clinical parameters were analyzed in the two groups. Results Admission Hb ~〈 100 g/L was the threshold value affecting postoperative pulmonary complications. The duration of time to initial passage of flatus and the ICU length of stay were significantly prolonged in patients with admission Hb values ~〈 100 g/L, in which poorer arterial blood gas analyses were common. Conclusions The admission Hb value of patients with cirrhosis- associated hepatocellular carcinoma affects the early-phase prognosis after LT.
出处 《中华普通外科杂志》 CSCD 北大核心 2012年第9期726-728,共3页 Chinese Journal of General Surgery
关键词 肝硬化 血红蛋白类 肝移植 肺部并发症 Cirrhosis Hemoglobins Liver transplantation Pulmonary complication
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  • 1Jensen JD, Jensen LW, Madsen JK, Poulsen L. The metabolism of erytbropoietin in liver cirrhosis patients compared with healthy volunteers. Eur J Haematol 1995; 54:111-116.
  • 2Cazzola M, Guamone R, Cerani P, Centenara E, Rovati A, Beguin Y. Red blood cell precursor mass as an independent determinant of serum erythropoietin level. Blood 1998; 91:2139-2145.
  • 3Krantz SB. Erythropoietin. Blood 1991; 77:419-434.
  • 4Canbolat O, Fandrey J, Jelkmann W. Effects of modulators of the production and degradation of hydrogen peroxide on erythropoietin syntesis. Respir Physiol 1998; 114:175-183.
  • 5Fandrey J, Frede S, Jelkmann W. Role of hydrogen peroxide in hypoxia-induced erythropoietin production. Biochem J 1994; 303:507-510.
  • 6Schobersberger W, Hoffmann G, Fandrey J. Nitric oxide donors suppress erythropoietin production in vitro. Pflugers Arch 1996;432:980-985.
  • 7Genius J, Fandrey J. Nitric oxide affects the production of reactive oxygen species in hepatoma cells: implications for the process of oxygen sensing. Free Radic Biol Med 2000; 29:515-521.
  • 8Faquin WC, Schneider TJ, Goldberg MA. Effect of inflammatory cytokines on hypoxia-induced erythropoietin production. Blood 1992; 79:1987-1994.
  • 9Jelkmann WE, Fandrey J, Frede S, Pagel H. Inhibition of erythropoietin production by cytokines. Implications for the anemia involved in inflammatory states. Ann N Y Acad Sci 1994; 718:300-309.
  • 10Poveda Gomez F, Camacho Siles J, Quevedo Morales E,Fernandez Zamorano A, Codoceo Alquinta R, Arnalich Fernandez F, Sempere Alcocer M. Pattern of blood levels of erythropoietin and proinflammatory cytokines in patients with anemia of chronic disorders secondary to infection. An Med Interna 2001; 18:298-304.

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