摘要
目的 研究二甲基奶油黄诱发的大鼠肝癌的组织学改变。方法 设对照组 (饲料中无DAB)和实验组 (饲料中含DAB) ,4周至 16周间分批处死动物 ,光镜和电镜下观察肝脏病变情况。结果 整个过程分为非特异性炎症、肝硬化、肝癌 3个阶段。非特异性炎症阶段光镜下改变为肝细胞气球样变性、炎性细胞浸润。肝硬化阶段表现为肝细胞和胆管腺瘤样增生 ,假小叶形成 ,肝组织炎性细胞浸润。肝癌有肝细胞癌、胆管细胞癌和混合细胞癌 3种组织类型。超微结构显示癌细胞间连接复合体减少 ,核膜增厚 ,线粒体减少。胆管细胞癌中发现致密核心颗粒。结论 在由二甲基奶油黄诱发的大鼠肝肿瘤中 。
Aim To study the histologic alterations of rat hepatic carcinomas induced by dimethylaminoazobenzene.Method Four groups of rats were fed with or without dimethylaminoazobenzene. All the rats were killed according different intervals of feeding.The liver pathologic alterations were observed by optical and electronic microscope.Result The proceeding of hepatic carcinoma was fell into non-specific inflammation、cirrhosis and hepatic carcinoma.There are balloon denaturalization of hepatocytes and infiltration of inflammation cells in non-specific inflammation stage under microscopy.There are hyperplastic nodules of hepatocytes、ductular adenomatous and the formation of false lobules in the cirrhosis stage.The pathologic types of hepatic carcinoma are hepatocellular carcinoma、cholangiocarcinoma and cholangio-hepatocellular carcinoma.The junctions among carcinoma cells were fewer,nuclear membrarames became thick.We found electron-dense core granules in cytoplasm of cholangiocarcinoma.Conclusion Histologic alterations and electron dense core granules could be found in dimethylaminoazobenzene induced rat hepatomas
出处
《胃肠病学和肝病学杂志》
CAS
2000年第1期17-19,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
二甲基奶油黄
肝细胞癌
超微结构
胆管癌
Dimethylaminoazobenzene Hepatocellular carcinoma Ultrastructure Cholangiocarcinoma
