摘要
应用二甲基奶油黄(DAB)诱发大鼠肝癌,整个过程分为非特异性炎症、肝硬化、肝癌3个阶段。诱癌后第12周开始出现肝癌,第20周时诱癌率达92.86%(13/14)。非特异性炎症阶段光镜下改变为肝细胞气球样变性、炎性细胞侵润。肝硬化阶段表现为肝细胞和胆管腺瘤样增生,假小叶形成,肝组织炎性细胞侵润。肝癌有肝细胞癌、胆管细胞癌和混合细胞癌3核膜增厚,线粒体减少。胆管细胞癌中发现致密核心颗粒,其意义有待进一步研究。
The proceed of hepatic carcinoma induced by DAB was fell into non-special inflam- mation、cirrhosis and hepatic carcinoma.The liver carcinoma appeared in the twelfth week after feeding by DAB.The rate of inducing carcinoma is 92.86% 13/14) in the twentieth week.There are balloon denaturalization of hepatocytes and invading inflammation cells in non-special inflam- mation stage under microscopy.There are formation of hyperplastic nodules of hepatocytes、duc- tular cystadenomatous and false lobule in the cirrhosis stage.The pathologic types are hepatocel- lular carcinoma、cholangicoar carcinoma and cholango-hepatocellular carcinoma.The junctions a- mong carcinoma cells was few,nuclear members became thick.We find electron-dense core gran- ules in cytoplasm of cholangiocellular carcinoma,and the meaning is to be studied.
