摘要
目的：探讨蜂胶提取物抗肿瘤及减轻化疗药物毒性的作用。方法：通过整体动物实验，将昆明小鼠移植S180肉瘤，观察蜂胶提取物抑制肿瘤作用及与化疗药物合用时的协同及减毒作用。结果：蜂胶提取物的抑瘤率为27．74％，与环磷酸胺合用的抑癌率为50．32％，比单用蜂胶提取物及环磷酸胺分别提高22．58％和9．03％（P＜0．05），并能减轻环磷酰胺所致的骨髓造血功能抑制，使血液白细胞维持在正常水平（P＜0．01）。结论：蜂胶提取物与环磷酰胺合用有协同抗肿瘤作用，并能减轻肿瘤化疗药物的毒副作用。
Purpose: To study propolis extract antitumor effect and its lowering of the toxicity caused by chemotherapeutant. Methods:Kunming mice transplanted with S180 sarcoma were used to study the inhibition effect of propolis extract on tumor,and its lowering of toxicity caused by synergy with chemotherapeutant. Results:The extract of propolis had certain antineoplasm effect and the inhibition rate of propolis extract on tumor is 27. 74% and when combined with cyclophosphamide, the inhibition rate reached to 5o. 32 %,even antagonized leucocytopenia caused by cyclophosphamide. Conclusion: The extract of propolis could relieve leucocytopenia and thrombocytopenia caused by chemotherapeuant clearly.
出处
《中国生化药物杂志》
CAS
CSCD
2000年第2期90-92,共3页
Chinese Journal of Biochemical Pharmaceutics
